+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Natural killer cytotoxicity and antibody-dependent cell cytotoxicity to herpes simplex virus-infected target cells in murine pregnancy



Natural killer cytotoxicity and antibody-dependent cell cytotoxicity to herpes simplex virus-infected target cells in murine pregnancy



American Journal of Reproductive Immunology and Microbiology 17(2): 53-56



In vitro natural killer cytotoxicity (NKC) and antibody-dependent cell cytotoxicity (ADCC) activity against herpes simplex virus (HSV)-infected cells were evaluated in a pregnant murine model (C57Bl6 inbred strain). Virgin (n = 16) and pregnant (late gestation) mice (n = 15) were infected intraperitoneally with HSV, type 1. After 18 hr, a 0.5-ml aliquot of the peritoneal wash was frozen for virus plaque assay, and the cells were cultured in the 51chromium release assay for NKC and ADCC. %NKC (mean +/- S.E.) to HSV-infected targets was significantly suppressed (P less than 0.05) in pregnant mice, 10.3% +/- 1.9, compared to that of virgin mice, 32.5% +/- 2.5. This suppression was abrogated with HSV-specific antisera (%ADCC); 53.9% +/- 4.4 (pregnant) compared to 49.1% +/- 3.6 (virgin). The diminished NKC activity in pregnant mice was reflected in an increased mean number of virus particles in the peritoneal wash, 266 +/- 66 PFU/ml, compared to 38 +/- 11 PFU/ml in virgin mice (P less than 0.05). We concluded that NKC, but not ADCC, to HSV-infected targets was suppressed and that HSV elimination was impaired in pregnant mice.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040775762

Download citation: RISBibTeXText

PMID: 2847568

DOI: 10.1111/j.1600-0897.1988.tb00202.x


Related references

Natural killer cell cytotoxicity and antibody-dependent cellular cytotoxicity to herpes simplex virus-infected cells in human pregnancy. American Journal of Reproductive Immunology and Microbiology 13(1): 23-26, 1987

Influence of naproxen therapy on natural killer cytotoxicity and antibody-dependent cellular cytotoxicity against cells infected with herpes simplex virus. Journal of Reproductive Medicine 29(10): 722-726, 1984

Human antibody-dependent cellular cytotoxicity and natural killer cytotoxicity to herpes simplex virus-infected autologous and allogeneic cells. Immunology 48(1): 187-193, 1983

Influence of menstrual cycle variations on natural killer cytotoxicity and antibody-dependent cellular cytotoxicity to cells infected with herpes simplex virus. Journal of Reproductive Medicine 30(6): 493-496, 1985

Analysis in human neonates of defective antibody-dependent cellular cytotoxicity and natural killer cytotoxicity to herpes simplex virus-infected cells. Journal of Infectious Diseases 150(1): 14-19, 1984

The effect of route of delivery on neonatal natural killer cytotoxicity and antibody-dependent cellular cytotoxicity to herpes simplex virus-infected cells. Pediatric Research 16(7): 558-560, 1982

Antibody-dependent cellular cytotoxicity and natural killer cytotoxicity of peritoneal cells from nude mice to herpes simplex virus-infected cells. Microbiology and Immunology 28(4): 439-449, 1984

Effect of herpes simplex virus infection on murine antibody-dependent cellular cytotoxicity and natural killer cytotoxicity. Infection and Immunity 31(2): 704-711, 1981

Murine antibody-dependent cellular cytotoxicity to herpes simplex virus-infected target cells. Journal of Immunology 123(1): 25-30, 1979

Natural killer cell cytotoxicity nkc to herpes simplex virus 1 hsv 1 infected cells is not altered by pregnancy. American Journal of Obstetrics & Gynecology 164(1 Part 2): 303, 1991

Natural killer cell cytotoxicity to herpes simplex virus-1-infected cells is not altered by pregnancy. American Journal of Obstetrics and Gynecology 165(4 Pt 1): 965-968, 1991

Natural killer cytotoxicity and antibody dependent cellular cytotoxicity in human herpes simplex virus infection. Archives Roumaines de Pathologie Experimentales et de Microbiologie 46(4): 333-346, 1987

Antibody-dependent cell-mediated cytotoxicity to herpes simplex virus type 2 infected target cells in the course of cervical carcinoma. American Journal of Epidemiology 108(2): 126-135, 1978

Antibody-dependent cell-mediated cytotoxicity to target cells infected with type 1 and type 2 herpes simplex virus. Journal of Immunology 116(1): 194-201, 1976

Immune modulation of natural killer cell cytotoxicity against herpes infected target cells in pregnancy. American Journal of Reproductive Immunology 24(4): 95-98, 1990