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Neoantigenic expression in enzyme-inhibitor complexes. A means to demonstrate activation of enzyme systems



Neoantigenic expression in enzyme-inhibitor complexes. A means to demonstrate activation of enzyme systems



Biochimica et Biophysica Acta 525(1): 287-290



Human thrombin-antithrombin III and plasmin-antiplasmin, two enzyme-inhibitor complexes composed of four different molecules, contain antigenic structures not present in the parent molecules, which can be directly quantitated in plasma with the use of non-cross-reacting antisera. It is anticipated that this neonatigenic expression is a more general phenomenon, which could provide a simple means of measuring activation of enzyme systems in biological fluids.

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Accession: 040780002

Download citation: RISBibTeXText

PMID: 150860

DOI: 10.1016/0005-2744(78)90222-x


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