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Neocarzinostatin: interaction between the antitumor-active chromophore and the carrier protein



Neocarzinostatin: interaction between the antitumor-active chromophore and the carrier protein



Journal of Biochemistry 109(6): 807-810



Conformational analysis of neocarzinostatin, an antibiotic protein with antitumor activity, in its holo-state in solution was carried out by NMR-spectroscopy. The results showed a beta-barrel structure for the carrier protein, in which the chromophore is tightly enwrapped and thus shielded from exposure to the solvent. The three-dimensional structure of this complex led to the proposal of a possible mechanism for the exposure or release of the active principle due to subtle environmental changes, e.g., in pH.

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Accession: 040780022

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PMID: 1834636

DOI: 10.1093/oxfordjournals.jbchem.a123462


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