+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neolacto (type-2 chain)-sialoautoantigens recognized by human cold agglutinins



Neolacto (type-2 chain)-sialoautoantigens recognized by human cold agglutinins



Vox Sanguinis 59(4): 235-239



The antigens Fl and Vo, recognized by cold agglutinins, are protease-resistant differentiation antigens like I and i antigens. In contrast to Ii, Fl and Vo are sialidase-susceptible antigens like the protease-resistant Gd antigens. Because I/i antigens are branched/linear type-2 (poly-N-acetyllactosamine or neolacto series) chains which are cleaved from red cells by endo-beta-galactosidase, the effect of the enzyme on Fl, Vo and Gd antigens was studied. Fl and Gd antigens, previously shown to be sialylated branched (Fl), and linear and branched (Gd) type-2 sequences, were not inactivated on red cells by the enzyme, whereas Vo antigenicity was completely abolished. The data suggest that Vo antigen is expressed on sialylated linear poly-N-acetyllactosamine sequence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040780187

Download citation: RISBibTeXText

PMID: 2127328

DOI: 10.1111/j.1423-0410.1990.tb00244.x


Related references

Sia-b1 and I antigens recognized by Mycoplasma pneumoniae-induced human cold agglutinins. Transfusion 31(7): 627-630, 1991

Polylactosamine sugar chains expressed by epithelia of Henle's loop and collecting duct in rat and human kidney are selectively recognized by human cold agglutinins anti-I/i. Tissue Antigens 44(3): 159-165, 1994

Structure of antigens recognized by cold agglutinins. Beitrage Zur Infusionstherapie und Transfusionsmedizin 33: 7, 1996

Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). Proceedings of the National Academy of Sciences of the United States of America 69(1): 40-43, 1972

Turnover of cold agglutinins and their cleavage products abstract human heavy and chain gamma m globulin. Acta Allergologica 22(6): 497, 1967

Glycolipid of human pancreatic cancer; the appearance of neolacto-series (type 2 chain) glycolipid and the presence of incompatible blood group antigen in tumor tissues. Biochimica et Biophysica Acta 1125(1): 21-27, 1992

Group-specific agglutinins in rabbit serums for human cells III Cold-agglutinins. Jour Immunol: 409-427, 1938

Group-specific agglutinins in rabbit serums for human cells. III. Cold-agglutinins. J. Immunol 34: 409-427, 1937

Light chain homogeneity of post infective cold agglutinins mycoplasma pneumoniae auto immune hemolytic anemia human. Clinical & Experimental Immunology 3(9): 923-929, 1968

Complement and cold agglutinins. I. Complement coating of normal human erythrocytes by cold agglutinins. Clinical and Experimental Immunology 2(2): 229-239, 1967

Anti-j: Human cold agglutinins recognizing linear (i) and branched (I) type 2 chains. Vox Sanguinis 67(2): 216-221, 1994

Evidence for structural diversity in light chains of kappa type human cold agglutinins. Immunochemistry 8(3): 265-269, 1971

Cold Agglutinins. Iii. Observations On Certain Serological And Physical Features Of Cold Agglutinins In Cases Of Primary Atypical Pneumonia And Of Hemolytic Anemia. Journal of Clinical Investigation 24(4): 474-482, 1945

Cold Agglutinins. Vi. Agglutinins For An Indifferent Streptococcus In Primary Atypical Pneumonia And In Other Conditions And Their Relation To Cold Isohemagglutinins. Journal of Clinical Investigation 24(4): 497-502, 1945

Chronic hemolytic anemia due to cold agglutinins: the mechanism of resistance of red cells to C' hemolysis by cold agglutinins. Journal of Clinical Investigation 46(9): 1461-1474, 1967