+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neonatal T4+ lymphocytes: analysis of the expression of 4B4 and 2H4 antigens



Neonatal T4+ lymphocytes: analysis of the expression of 4B4 and 2H4 antigens



Clinical Immunology and Immunopathology 46(1): 61-67



Using monoclonal antibodies anti-2H4 and anti-4B4 we investigated by double immunofluorescence and immunorosette technique the presence of cells displaying the helper-inducer and the inducer of suppression phenotype among T4+ cord blood cells. The analysis of the estimated frequencies of subpopulations of T4+ cells shows that a high percentage of T4+ cord blood cells can coexpress both antigens in comparison to adult. Furthermore the percentage of T4+ cells with helper-inducer phenotype (2H4-4B4+) is significantly lower than that in the adult, while the percentage of T4+ cells with suppressor-inducer phenotype (2H4+4B4-) although higher, is not significantly different. These findings suggest that the relative immunoincompetence observed in the newborn may result from a variety of mechanisms including a low percentage of helper-inducer (4B4+2H4-) T4+ lymphocytes possibly also associated to an increased number of suppressor-inducer T4+ cells (2H4+4B4-).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040780297

Download citation: RISBibTeXText

PMID: 2961493

DOI: 10.1016/0090-1229(88)90006-2


Related references

Neonatal t4 positive lymphocytes analysis of the expression of 4b4 and 2h4 antigens. Clinical Immunology & Immunopathology 46(1): 61-67, 1988

Expression of Thomsen-Friedenreich (TF) antigens on lymphocytes. II. Loss of cryptic TF antigens during mitogenic activation of human T and B lymphocytes. Cellular Immunology 121(2): 366-371, 1989

Expression of thomsen friedenreich tf antigens on lymphocytes i. distribution of cryptic and exposed tf antigens on murine lymphocytes from different lymphoid organs detection with an anti tf monoclonal antibody and peanut agglutinin. Cellular Immunology 121(2): 360-365, 1989

Lymphokine activated killer activity induced by in vivo interleukin 2 therapy predominant role for lymphocytes with increased expression of cd2 and leu19 antigens but negative expression of cd16 antigens. Cancer Research 49(13): 3680-3688, 1989

The expression of hla dr dq and dp antigens on the surface of lymphocytes as assessed by 2 dimensional polyacrylamide gel analysis of immunoprecipitates. Albert, E D , M P Baur And W R Mayr (Ed ) Histocompatability Testing ; 9th International Workshop And Conference, Munich, West Germany, May 6-11, ; Vienna, Austria, May 13-15, Xxvii+764p Springer-Verlag: New York, N Y , Usa; Berlin, West Germany Illus 545-549, 1984

Expression of red cell antigens C and c on neonatal and adult erythrocytes: A flow-cytometric analysis. Vox Sanguinis 63(1): 53-55, 1992

Analysis of the expression of cell surface antigens and intercellular adhesion molecules on lymphocytes in CAPD patients. Nihon Jinzo Gakkai Shi 37(2): 134-139, 1995

Expression of hla dr antigens in naso pharyngeal carcinoma an immuno histological analysis of the tumor cells and infiltrating lymphocytes. International Journal of Cancer 33(6): 813-820, 1984

Differential expression of T cell antigens in normal peripheral blood lymphocytes: a quantitative analysis by flow cytometry. Journal of Clinical Pathology 49(7): 539-544, 1996

Analysis by flow cytometry of differentiation antigens expression on human colonic carcinoma cells and infiltrating lymphocytes. Analytical Cellular Pathology 6(3): 225, 1994

A two-label microfluorometric analysis of the expression of OKT5 and Leu 2a antigens on peripheral blood lymphocytes in patients with multiple sclerosis. Journal of Neuroimmunology 6(2): 85-92, 1984

The different effect of alpha and gamma interferons and interleukin 2 on the expression of CD2, CD3, CD4 and CD8 antigens in comparison to histocompatibility antigens of human lymphocytes. Immunology Letters 18(4): 259-268, 1988

A double-label flow cytometric analysis of the simultaneous expression of OKT4 and Leu2a antigens on circulating T lymphocytes in myasthenia gravis. Journal of Neuroimmunology 11(4): 311-319, 1986

Neonatal murine B lymphocytes respond to polysaccharide antigens in the presence of IL-1 and IL-6. Journal of Immunology 161(7): 3315-3324, 1998

Studies on the induction and expression of T cell-mediated immunity. IV. Non-overlapping populations of alloimmune cytotoxic lymphocytes with specificity for tumor-associated antigens and transplantation antigens. Journal of Immunology 115(5): 1301-1308, 1975