+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neonatal alloimmune thrombocytopenia. Serological studies

Neonatal alloimmune thrombocytopenia. Serological studies

Tidsskrift for den Norske Laegeforening 111(10): 1233-1235

Alloimmune neonatal thrombocytopenia is most often caused by immunization towards the platelet-specific, glycoprotein IIIa-associated antigen HPA-1a (previous nomenclature PlA1, Zwa), but other defined platelet-specific antigens may also be involved. An HPA-1a-negative mother carrying an HPA-1a-positive child occurs in 1/50 of all pregnancies. However, HPA-1a-immunization occurs only in 1/1000 of all pregnancies, and only a proportion of the children are clinically affected. If the mother is positive for HLA-B8/DR3 she is known to be at risk for immunization. The serological diagnosis of thrombocyte immunization requires careful typing and investigation of antibodies, and reliable typing reagents. The quantitation of the mother's antibody is of little predictive value for the child's outcome, but intrauterine cord sampling can be a useful tool for improving the prenatal diagnosis.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040780347

Download citation: RISBibTeXText

PMID: 2042131

Related references

Contemporary management of neonatal alloimmune thrombocytopenia: good outcomes in the intravenous immunoglobulin era: results from the Australian neonatal alloimmune thrombocytopenia registry. Journal of Maternal-Fetal and Neonatal Medicine 30(20): 2488-2494, 2017

Neonatal alloimmune thrombocytopenia - serological investigations in 2006. 2007

Clinical and serological findings in alloimmune neonatal thrombocytopenia. Connecticut Medicine 50(4): 220-224, 1986

Recommendations for the evaluation and treatment of neonatal autoimmune and alloimmune thrombocytopenia. The Working Party on Neonatal Immune Thrombocytopenia of the Neonatal Hemostasis Subcommittee of the Scientific and Standardization Committee of the ISTH. Thrombosis and Haemostasis 65(5): 631-634, 1991

Simultaneous occurrence of neonatal alloimmune thrombocytopenia and neonatal alloimmune neutropenia. Vox Sanguinis 83(Suppl. 2): 81, 2002

A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy. International Journal of Hematology 100(4): 398-401, 2014

Studies of 219 zw a positive mothers of children with clinically suspected neonatal alloimmune thrombocytopenia. Kretschmer, V , W Stangel And W Sachs (Ed ) Beitraege Zur Infusionstherapie, Band 26 Transfusionsmedizin 1989/90; (Contributions to Infusion Therapy, Vol 26 Transfusion Medicine 1989/90; 23rd Congress Of The German Society For Transfusion Medicine And Immunohematology), Kiel, Germany, September 5-9, 1989 Xxii+453p S Karger Ag: Basel, Switzerland; New York, New York, Usa Illus 397-400, 1990

Neonatal alloimmune thrombocytopenia nait studies with a quantitative competitive igg elisa celisa and immunoblotting. Blut 55(4): 288, 1987

A novel platelet-reactive alloantibody in neonatal alloimmune thrombocytopenia and phocomelia with hypoplastic thrombocytopenia. British Journal of Haematology 86(Suppl. 1): 55, 1994

Clinical and diagnostic comparison of neonatal alloimmune thrombocytopenia to non-immune cases of thrombocytopenia. Pediatric Blood & Cancer 45(2): 176-183, 2005

Guidelines on the investigation and management of thrombocytopenia in pregnancy and neonatal alloimmune thrombocytopenia. British Journal of Obstetrics and Gynaecology 104(10): 1108, 1997

From an early National Blood Foundation award to our ongoing studies in fetal and neonatal alloimmune thrombocytopenia. Transfusion 45(2 Suppl.): 64s-66s, 2005

Neonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia. British Medical Journal 281(6232): 27, 1980

Alloimmune neonatal thrombocytopenia associated with incidental maternal thrombocytopenia. American Journal of Hematology 35(1): 43-44, 1990

Screening primiparous women and newborns for fetal/neonatal alloimmune thrombocytopenia: a prospective comparison of effectiveness and costs. Immune Thrombocytopenia Working Group. American Journal of Perinatology 13(7): 423-431, 1996