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Neonatal alloimmune thrombocytopenia. Serological studies



Neonatal alloimmune thrombocytopenia. Serological studies



Tidsskrift for den Norske Laegeforening 111(10): 1233-1235



Alloimmune neonatal thrombocytopenia is most often caused by immunization towards the platelet-specific, glycoprotein IIIa-associated antigen HPA-1a (previous nomenclature PlA1, Zwa), but other defined platelet-specific antigens may also be involved. An HPA-1a-negative mother carrying an HPA-1a-positive child occurs in 1/50 of all pregnancies. However, HPA-1a-immunization occurs only in 1/1000 of all pregnancies, and only a proportion of the children are clinically affected. If the mother is positive for HLA-B8/DR3 she is known to be at risk for immunization. The serological diagnosis of thrombocyte immunization requires careful typing and investigation of antibodies, and reliable typing reagents. The quantitation of the mother's antibody is of little predictive value for the child's outcome, but intrauterine cord sampling can be a useful tool for improving the prenatal diagnosis.

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Accession: 040780347

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PMID: 2042131


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