+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neonatal effects of propofol administered to the mother in anesthesia in cesarean section



Neonatal effects of propofol administered to the mother in anesthesia in cesarean section



Cahiers d'Anesthesiologie 37(6): 429-433



Propofol, 2-6 diisopropylphenol ("Diprivan", ICI) has been shown to be safe and effective for induction and maintenance of anesthesia when injected intravenously. Its pharmacological profile suggests that it may prove to be a useful agent in obstetric anesthetic practice. But, obstetrics is a specialized field in which the acute effects of the anesthetic agent on the fetus must be considered. This open non comparative study was therefore designed to investigate the neonatal assessments when propofol was used either for induction of anesthesia or for induction and maintenance of anesthesia during elective cesarean section. This study was conducted in two separate phases according to the use of propofol. In both phases, anesthesia was induced with an intravenous bolus of 2.5 mg.kg-1 of propofol. In phase 1 (n = 10), anesthesia was maintained with 50% nitrous oxide in oxygen and halothane. In phase 2 (n = 11), a continuous infusion of propofol at a rate of 5 mg.kg-1.h-1 was started after the induction dose. At time of delivery, blood samples were taken from maternal artery, umbilical vein and artery for acid-base and blood gas status. The condition of the infant was evaluated using Apgar score at 1, 5 and 10 min, time to sustained spontaneous respiration and the Neurologic and Adaptative Capacity Score was assessed at 30 min, 2 hours and 24 hours after birth. Maternal and neonatal blood gas tensions and acid-base status at delivery were within the normal clinical limits in both phases and compared favorably with results published by others workers using established methods of anesthesia.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040780768

Download citation: RISBibTeXText

PMID: 2605537


Related references

Placental transfer and neonatal effects of propofol administered during cesarean section. Anesthesiology 67(3A): A454, 1987

Anesthesia for cesarean section--VII. Early effects on neonatal renal function of enflurane anesthesia for cesarean section. Acta Anaesthesiologica Scandinavica 24(3): 190-194, 1980

Influence of cesarean section and of anesthesia given to the mother on neonatal bilirubinemia. Minerva Pediatrica 17(29): 1532-1543, 1965

Computer -Simulated Analysis of Propofol and Fentanyl Concentration To Avoid Neonatal Depression during Cesarean Section under General Anesthesia. Anesthesiology Abstracts of Scientific Papers Annual Meeting ( ): Abstract No A-1209, 2003

Anesthesia for cesarean section IV: placental transfer and neonatal elimination of bupivacaine following epidural analgesia for elective cesarean section. Acta Anaesthesiologica Scandinavica 20(2): 141-146, 1976

Anesthesia for cesarean section V: effects of enflurane anesthesia on the respiratory adaptation of the newborn in elective cesarean section. Acta Anaesthesiologica Scandinavica 20(2): 147-155, 1976

Standardized General Anesthesia in Cesarean Section and its Effects on Electrocardiography of the Mother, Infant and Fetus. Obstetrical and Gynecological Therapy 9: 493-500, 1964

Neonatal Effects after Vasopressor During Spinal Anesthesia for Cesarean Section. Obstetric Anesthesia Digest 38(3): 141-142, 2018

The maternal and neonatal effects of desflurane anesthesia and cesarean section. Anesthesiology 77(3A): A996, 1992

Pharmacokinetics, placental transfer, and neonatal effects of vecuronium and pancuronium administered during cesarean section. Anesthesiology 60(6): 569-574, 1984

Intravenous propofol during cesarean section: placental transfer, concentrations in breast milk, and neonatal effects. A preliminary study. Anesthesiology 71(6): 827-834, 1989

Neonatal effects of delivery interval during cesarean section under spinal anesthesia. Acta Obstetrica et Gynaecologica Japonica (Japanese Edition) 38(12): 2207-2213, 1986

Comparison of neonatal effects of epidural and general anesthesia for cesarean section. Gynecologic and Obstetric Investigation 55(1): 41-45, 2003

Neonatal effects of the delivery interval during cesarean section under spinal anesthesia. Nihon Sanka Fujinka Gakkai Zasshi 38(12): 2207-2213, 1986

General anesthesia by propofol infusion for delivery by cesarean section compared with sevoflurane anesthesia using bispectral index (BIS) monitoring. Masui. Japanese Journal of Anesthesiology 54(4): 408-413, 2005