+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neonatal exposure to DES in BALB/c male mice: effects on pituitary-gonadal function

Neonatal exposure to DES in BALB/c male mice: effects on pituitary-gonadal function

Pharmacology Biochemistry and Behavior 22(6): 1019-1024

Neonatal male BALB/c mice were injected with diethylstilbestrol (DES), estradiol benzoate (E2B), testosterone propionate (TP), progesterone or DES, in combination with E2B, TP or progesterone and examined in adulthood. Body weight was reduced in males exposed to DES, TP or DES + TP, while testicular weight was reduced in animals injected with DES, E2B, TP, DES + TP or DES + progesterone. Exposure to DES and/or E2B also produced reproductive tract abnormalities and concomitant progesterone exposure did not further affect this parameter. Concomitant DES did not further alter the reduced plasma luteinizing hormone (LH) levels attributable to neonatal TP or E2B treatment. Plasma follicle-stimulating hormone (FSH) levels in intact males were increased by DES, DES + progesterone or progesterone alone. Assessment of the feedback effects of exogenous gonadal steroids on pituitary gonadotropin release in castrated adults indicated that injection of 125 micrograms TP further increased the already elevated post-castration levels of LH and FSH in mice neonatally exposed to progesterone. The increase in testosterone (T) concentration after intratesticular human chorionic gonadotropin (hCG) administration was significantly attenuated in mice neonatally exposed to DES plus E2B or to progesterone. Basal testicular T levels were significantly elevated in males exposed to DES, alone, or in combination with progesterone. Exposure to DES and TP increased hypothalamic serotonin (5-HT) levels in intact mice, while levels of 5-HT were lower after castration compared to controls. DES + E2B-treated mice had higher norepinephrine (NE) levels, and E2B-treated mice also had higher 5-HT levels.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 040780803

Download citation: RISBibTeXText

PMID: 3927323

DOI: 10.1016/0091-3057(85)90312-0

Related references

Neonatal exposure to diethylstilbestrol in balb c male mice effects on pituitary gonadal function. Pharmacology Biochemistry & Behavior 22(6): 1019-1024, 1985

Effects of the gonadotrophin-releasing hormone agonist 'Zoladex' upon pituitary and gonadal function in hypogonadal (hpg) male mice: a comparison with normal male and testicular feminized (tfm) mice. Journal of Molecular Endocrinology 8(3): 249-258, 1992

Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice. 2013

Specific and weight loss-associated effects of one-week exposure to ethanol on pituitary-gonadal function of male rats. Acta Endocrinologica 119(1): 99, 1988

Effects of 1800 MHz GSM-like exposure on the gonadal function and hematological parameters of male mice. Magyar Onkologia 49(2): 149-151, 2005

Long-term effects of neonatal administration of estrogen and progesterone, alone or in combination, on male BALB/c and BALB/cfC3H mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 165(1): 17-25, 1980

The effects of neonatal androgenization of male rats on testosterone metabolism by the hypothalamus-pituitary-gonadal axis. Journal of Steroid Biochemistry 26(4): 493-497, 1987

Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats. Reproduction 121(6): 915-924, 2001

Late effects of neonatal undernutrition and overnutrition on pituitary-thyroidal and gonadal function. Biology of the Neonate 27(3-4): 259-270, 1975

Effects of danazol on the pituitary-gonadal axis in male gerbils and mice. Fertility and Sterility 26(1): 68-73, 1975

Effects of alcohol administration of the pituitary gonadal function in male rats. Anatomical Record 229(4): 28A, 1991

Effects of centrifugation stress on pituitary-gonadal function in male rats. Journal of Applied Physiology: Respiratory Environmental and Exercise Physiology 48(1): 1-5, 1980

Effects of a non-steroidal antiandrogen on sexual behavior and pituitary-gonadal function in the male rat. Endocrinology 97(6): 1468-1475, 1975

Effects of d 6 tryptophanyl lhrh on pituitary gonadal function in male rhesus monkeys. Journal of Andrology 2(1): 28, 1981