+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neonatal exposure to a high level of ACTH4-10 impairs adult learning performance



Neonatal exposure to a high level of ACTH4-10 impairs adult learning performance



Pharmacology Biochemistry and Behavior 27(1): 133-142



Male offspring of Sprague-Dawley dams were injected with 25 micrograms of ACTH4-10 or the vehicle on days 2 through 7 postpartum. Peptide treated animals exhibited a marked motor response to the peptide injection. Adrenal weights of these animals were consistently heavier than littermate controls in both the developing and adult animals. ACTH4-10 treated neonates exhibited significantly poorer learning performance in the shuttle box and were slower to acquire the reversal learning problem of a visual discrimination task under light shock levels. In addition, these animals also exhibited an exaggerated startle response and a stronger thigmotaxis response in the open field than controls. These results indicate that exposing the developing nervous system to relatively high levels of ACTH4-10 can produce marked long-term effects on behavior.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040780804

Download citation: RISBibTeXText

PMID: 3039538

DOI: 10.1016/0091-3057(87)90487-4


Related references

Embryonic alcohol exposure impairs associative learning performance in adult zebrafish. Behavioural Brain Research 265: 181-187, 2014

Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats. European Journal of Neuroscience 24(3): 857-866, 2006

Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning, and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicology and Applied Pharmacology 192(2): 95-106, 2003

Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice. Toxicological Sciences 92(1): 211-218, 2006

Neonatal chlordecone exposure impairs early learning and retention of active avoidance in the rat. Neurobehavioral Toxicology and Teratology 6(1): 75-83, 1984

Chronic low-level lead exposure impairs serial reversal learning in the rat. Society for Neuroscience Abstracts 20(1-2): 1655, 1994

Chronic stress in the neonatal rat impairs hippocampus mediated learning and memory functions in the adult. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 274 4, 2002

Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory. Toxicology Letters 232(1): 263-270, 2015

Neonatal gamma-ray irradiation impairs learning and memory of an olfactory associative task in adult rats. European Journal of Neuroscience 9(5): 884-894, 1997

Adolescent exposure to nicotine impairs adult serial pattern learning in rats. Experimental Brain Research 187(4): 651-656, 2008

Neonatal alcohol exposure impairs acquisition of eyeblink conditioned responses during discrimination learning and reversal in weanling rats. Developmental Psychobiology 49(3): 243-257, 2007

A long-term stress exposure impairs maze learning performance in rats. Neuroscience Letters 273(2): 125-128, 1999

Neonatal exposure to 65% oxygen durably impairs lung architecture and breathing pattern in adult mice. Chest 123(2): 530-538, 2003

Prolonged in utero meconium exposure impairs spatial learning in the adult rat. Central Prize Award. American Journal of Obstetrics and Gynecology 190(6): 1551-5; Discussion 1555-6, 2004