+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Neurobehavioral study of the effect of beta-myrcene on rodents

Neurobehavioral study of the effect of beta-myrcene on rodents

Brazilian Journal of Medical and Biological Research 24(8): 827-831

Tea prepared from lemongrass (Cymbopogon citratus) is used for its supposed anxiolytic, hypnotic and analgesic properties in Brazilian folk medicine. beta-Myrcene, a major constituent of lemongrass, produces analgesia in rodents but there is some controversy about whether this action is central or peripheral or both. Rats and mice received beta-myrcene, 1 g/kg po in corn oil, or corn oil alone 1 h before being evaluated for a series of responses which included exploratory and emotional behavior, anxiolytic activity in a plus maze and inhibition of conditioned avoidance. No evidence was demonstrable for an effect of beta-myrcene on any of these behaviors. Similarly, beta-myrcene had no protective effect on pentylenetetrazol (PTZ)-induced seizures in mice. These data suggest that beta-myrcene has no benzodiazepine-like anxiolytic activity and that an activity on the central nervous system (antidepressive or antipsychotic) is unlikely. Despite the negative results of this study, folk use of lemongrass tea may still be justified by its analgesic properties.

(PDF emailed within 1 workday: $29.90)

Accession: 040786197

Download citation: RISBibTeXText

PMID: 1797273

Related references

Study on embryo-foetotoxicity of beta-myrcene in the rat. Food and Chemical Toxicology 31(1): 31-35, 1993

Effect of beta-myrcene on pentobarbital sleeping time. Brazilian Journal of Medical and Biological Research 26(5): 519-523, 1993

Study of the effects of beta-myrcene on rat fertility and general reproductive performance. Brazilian Journal of Medical and Biological Research 31(7): 955-965, 1998

Single dose toxicity study of beta-myrcene, a natural analgesic substance. Brazilian Journal of Medical and Biological Research 23(9): 873-877, 1990

Chemical study of essential oils derived from biota orientalis g and cupressus sempervirens g cultivated in azerbaidzhan ussr inst chromatography alpha pinene beta pinene myrcene limonene caryophyllene farnesene beta bisabolene cedrol bisabolol delta cadinene. Farmatsiya: 33-39, 1968

Neurobehavioral screening in rodents. Current Protocols in Toxicology Chapter 11: Unit11.2, 2011

Beta-myrcene - a component of turpentines from P. sylvestris.. Dokl. Akad. Nauk SSSR., 71: 4, 673-5, 1953

Induction of liver monooxygenases by beta-myrcene. Toxicology 124(2): 135-140, 1998

Terpenoids part 69 a new synthesis of beta myrcene. Indian Journal of Chemistry 11(2): 104-105, 1973

Bioconversion of beta-myrcene to perillene by Pleurotus ostreatus. Biocatalysis and Biotransformation 26(4): 288-295, 2008

Microbial conversion of .BETA.-myrcene by Aspergillus niger. Agricultural and Biological Chemistry 52(11): 2921-2922, 1988

Peri- and postnatal developmental toxicity of beta-myrcene in the rat. Food and Chemical Toxicology 31(9): 623-628, 1993

Microbial conversion of beta myrcene by aspergillus niger. Agricultural & Biological Chemistry 52(11): 2921-2922, 1988

The Revised Neurobehavioral Severity Scale (NSS-R) for Rodents. Current Protocols in Neuroscience 75: 9.52.1-9.52.16, 2016

Selective receptor neurone responses to E-beta-ocimene, beta-myrcene, E,E-alpha-farnesene and homo-farnesene in the moth Heliothis virescens, identified by gas chromatography linked to electrophysiology. Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology 186(9): 833-847, 2000