+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neuropsychological effects of short-term discontinuation of oxygen therapy. Observations in patients with chronic hypoxemia who are receiving long-term oxygen therapy



Neuropsychological effects of short-term discontinuation of oxygen therapy. Observations in patients with chronic hypoxemia who are receiving long-term oxygen therapy



Archives of Internal Medicine 146(8): 1557-1559



Twelve patients receiving long-term oxygen therapy were assessed for possible detrimental neuropsychological effects of short-term withdrawal of oxygen. Patients served as their own controls and received either their usual oxygen prescriptions or room air, through nasal prongs, over four-hour periods on two successive days. A battery of neuropsychological tests assessing memory and learning, sustained concentration, and motor and visuomotor speed were administered. In the room-air condition, the mean arterial oxygen partial pressure fell from 86.1 +/- 25.7 to 59.1 +/- 11.7 mm Hg, and the mean oxygen saturation fell from 94.7% +/- 3.2% to 89.9% +/- 5.3%, but the mean carbon dioxide partial pressure did not change significantly. No significant differences in neuropsychological test scores were found between the two conditions, suggesting that four hours of mild hypoxemia causes no significant deficits in cognition in patients receiving long-term oxygen therapy. Paradoxically, low-order inverse correlations were found between arterial oxygen partial pressures and results of visuomotor speed and memory tests, suggesting that an improvement in performance may have taken place during oxygen withdrawal.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040793104

Download citation: RISBibTeXText

PMID: 3729636


Related references

Short term discontinuation of oxygen causes no immediate detrimental change in neuropsychological function in patients on long term oxygen therapy. American Review of Respiratory Disease 131(4 Suppl.): A315, 1985

Effects of long-term oxygen therapy due to portable liquid oxygen tanks in disabled malnourished chronic obstructive pulmonary disease patients with borderline hypoxemia. Aim of the study and methods. Respiration; International Review of Thoracic Diseases 59(Suppl. 2): 40, 1992

Adherence to ambulatory oxygen therapy. Assessment and determinants in patients receiving long-term oxygen therapy. Revue des Maladies Respiratoires 28(7): 873-880, 2011

Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. Copd 9(1): 3, 2012

Long-Term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease and Moderate Hypoxemia. Journal of the American Osteopathic Association 118(10): 663-665, 2018

Neuropsychological effects of long-term oxygen therapy in chronic obstructive pulmonary disease. European Respiratory Journal Suppl. 10(25): 447S, 1997

Nocturnal hypoxemia and long term oxygen therapy in copd patients with daytime arterial oxygen partial pressure 60 70 millimeters mercury. Lung 168(Suppl.): 770-775, 1990

Reversal of sexual impotence in male patients with chronic obstructive pulmonary disease and hypoxemia with long term oxygen therapy. Journal of Steroid Biochemistry & Molecular Biology 46(6): 799-803, 1993

Effects of oxygen supplementation on cerebral oxygenation during exercise in chronic obstructive pulmonary disease patients not entitled to long-term oxygen therapy. Clinical Physiology and Functional Imaging 32(1): 52-58, 2012

Survival of patients with chronic obstructive pulmonary disease receiving long-term domiciliary oxygen therapy. American Review of Respiratory Disease 147(3): 585-591, 1993

Predictors of survival in patients with chronic obstructive pulmonary disease receiving long-term oxygen therapy. Bmj Supportive and Palliative Care 4(2): 140-145, 2014

Effects of long term oxygen therapy in patients with idiopathic pulmonary fibrosis. II. Effect of oxygen therapy on function of heart ventricles. Polskie Archiwum Medycyny Wewnetrznej 94(4): 337-341, 1995

Long-term oxygen therapy in COPD patients with moderate hypoxemia. European Respiratory Journal Suppl. 9(23): 245S, 1996

Electrocardiographic changes and mortality risk in patients with chronic obstructive pulmonary disease receiving long-term oxygen therapy. European Respiratory Journal 12(Suppl. 28): 17S, 1998

Effects of Pulmonary Rehabilitation on the Survival of Emphysema Patients Receiving Long-term Oxygen Therapy. PhysioTherapy 85(5): 251-258, 1999