+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neuropsychological test performance, brain morphological measures and CSF monoamine metabolites in schizophrenic patients



Neuropsychological test performance, brain morphological measures and CSF monoamine metabolites in schizophrenic patients



Acta Psychiatrica Scandinavica 74(3): 292-301



Twenty-three drug-free patients with an acute schizophrenic psychosis were studied by clinical rating scales, neuropsychological tests, computed tomography (CT) of the brain and analysis of monoamine metabolites in the cerebrospinal fluid (CSF). The psychological tests used were the Swedish version of the Wechsler-Bellevue Intelligence scale (WBI) and the Block Design test. The patients' performance in the Block Design test was negatively correlated to the width of the third and lateral ventricles. Test profiles indicative of schizophrenic cognitive impairment and left hemisphere dysfunction correlated significantly with a wide third ventricle, but not with the size of the lateral ventricles. Patients with a test profile indicative of left hemisphere dysfunction also had wider Sylvian fissures than the remaining patients. Neuropsychological test scores did not correlate with the CSF levels of the monoamine metabolites HVA, MHPG and 5-HIAA. Positive psychotic and autistic symptoms did not correlate with psychological test results, monoamine metabolites or with CT measures. The association between neuropsychological impairment and enlargement of the brain ventricles is in line with previous findings indicating that a subgroup of schizophrenic patients may be identified by neuropsychological and morphological methods.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040793271

Download citation: RISBibTeXText

PMID: 3788656


Related references

Brain metabolism in Alzheimer's dementia: studies of 11C-deoxyglucose accumulation, CSF monoamine metabolites and neuropsychological test performance in patients and healthy subjects. Journal of Neurology Neurosurgery and Psychiatry 54(8): 672-678, 1991

Brain metabolism in alzheimer's dementia studies of carbon 11 deoxyglucose accumulation csf monoamine metabolites and neuropsychological test performance in patients and healthy subjects. Journal of Neurology Neurosurgery and Psychiatry 54(8): 672-678, 1991

Vasopressin levels in CSF of Alzheimer patients: correlations with monoamine metabolites and neuropsychological test performance. Psychoneuroendocrinology 14(1-2): 89-95, 1989

Neuropsychological test performance and CSF levels of monoamine metabolites in healthy volunteers and patients with Alzheimer's dementia. Acta Psychiatrica Scandinavica 76(6): 648-656, 1987

Relationship of whole brain volume MRI measures to neuropsychological performance in schizophrenic and healthy subjects. Schizophrenia Research 41(1): 122-123, 2000

Performance of chronic schizophrenic patients on cognitive neuropsychological measures sensitive to dementia. International Journal Of Geriatric Psychiatry. 11(7): 621-627, 1996

Decreased spinal fluid monoamine metabolites and norepinephrine in schizophrenic patients with brain atrophy. Beckmann, H And P Riederer (Ed ) Pathochemical Markers in Major Psychoses; Symposium, Vienna, Austria, July 1983 X+158p Springer-Verlag: New York, N Y , Usa; Berlin, West Germany Illus 88-95, 1985

The neuropsychological performance of the schizophrenic patients on luria's test. Indian Journal of Psychological Medicine 11(1): 11-12, 1988

Neuropsychological test performances of paranoid schizophrenic and brain-damaged patients. Journal of Clinical Psychology 35(1): 54-59, 1979

Relations between neuropsychological performance and brain morphological and physiological measures in monozygotic twins discordant for schizophrenia. Psychiatry Research 55(1): 51-61, 1994

Neuropsychological differences between schizophrenic patients with heterogeneous Wisconsin card sorting test performance. Schizophrenia Research. 21(1): 13-18, 1996

Discrimination between schizophrenic and brain-damaged patients with the Luria Nebraska Neuropsychological Test Battery. International Journal of Neuroscience 10(2-3): 121-128, 1980

A study on morphological abnormalities of the brain of schizophrenic patients using CT: The relationships between clinical backgrounds, psychiatric symptoms and neuropsychological impairment. Yamagata Medical Journal 17(1): 87-97, 1999

Level versus pattern of neuropsychological performance among schizophrenic and diffusely brain-damaged patients. Journal of Consulting and Clinical Psychology 47(1): 155-163, 1979

Performance on neuropsychological test of prefrontal lobe function and polymorphism of dopaminergic system genes in schizophrenic patients. American Journal of Medical Genetics 122B(1): 66, 2003