+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nicotine induced locomotor activity in rats: the role of Pavlovian conditioning



Nicotine induced locomotor activity in rats: the role of Pavlovian conditioning



Pharmacology Biochemistry and Behavior 29(4): 661-665



Rats repeatedly exposed to small doses of nicotine will demonstrate a significant augmentation of locomotor activity in response to a subsequent test dose of nicotine. A sensitization of brain tissue is hypothesized to account for this effect but Pavlovian conditioning might also be a major factor. Therefore the present study assessed the possible role of Pavlovian conditioning in this nicotine effect. Two experiments were conducted. In the first, subjects were administered either saline or nicotine in either their home cages or in activity test cages for five days. All subjects were then tested in the activity test cages on day six. In the second experiment rats were administered either nicotine or saline in the presence of a complex stimulus and later tested for response to nicotine alone and the complex stimulus alone. Results from these experiments indicate that Pavlovian conditioning does not play a major role in nicotine's effect on locomotor activity.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040806415

Download citation: RISBibTeXText

PMID: 3413193

DOI: 10.1016/0091-3057(88)90184-0


Related references

Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behavioural Brain Research 197(2): 323-330, 2009

Inhibitory actions of mGlu4 receptor ligands on cocaine-, but not nicotine-, induced sensitizing and conditioning locomotor responses in rats. Pharmacological Reports 66(2): 205-211, 2014

Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD). Behavioural Brain Research 291: 184-188, 2015

Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats. Behavioural Pharmacology 15(3): 183-194, 2004

Characterization of nicotine's ability to serve as a negative feature in a Pavlovian appetitive conditioning task in rats. Psychopharmacology 184(3-4): 470-481, 2005

Acute effects of nicotine injection into the nucleus accumbens on locomotor activity in nicotine-naive and nicotine-tolerant rats. Pharmacology Biochemistry and Behavior 37(4): 743-746, 1990

The hippocampus and appetitive Pavlovian conditioning: effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping. Hippocampus 15(6): 713-721, 2005

Nicotine as a signal for the presence or absence of sucrose reward: a Pavlovian drug appetitive conditioning preparation in rats. Psychopharmacology 172(1): 108-117, 2004

Influence of sex and female hormones on nicotine-induced changes in locomotor activity in rats. Pharmacology Biochemistry & Behavior 62(1): 179-187, 1999

The role of locomotion in conditioning methylphenidate-induced locomotor activity. Pharmacology Biochemistry and Behavior 4(4): 393-395, 1976

The effects of nicotine exposure during Pavlovian conditioning in rats on several measures of incentive motivation for a conditioned stimulus paired with water. Psychopharmacology 231(11): 2261-2271, 2014

Conditioning of morphine induced locomotor activity and stereotyped behavior in rats. Journal of Neural Transmission 78(3): 231-248, 1989

Nicotine-induced locomotor activity is increased by preexposure of rats to prenatal stress. Brain Research 882(1-2): 196-200, 3 November, 2000

Failure of alpha-bungarotoxin to modify nicotine-induced changes in locomotor activity in rats. British Journal of Pharmacology 120(PROC Suppl. ): 275P, 1997