+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nitrendipine treatment in so-called therapy-resistant arterial hypertension; effect as monotherapy and in combination with propranolol on blood pressure, heart rate, other hemodynamic parameters, plasma renin activity, and catecholamines



Nitrendipine treatment in so-called therapy-resistant arterial hypertension; effect as monotherapy and in combination with propranolol on blood pressure, heart rate, other hemodynamic parameters, plasma renin activity, and catecholamines



Journal of Cardiovascular Pharmacology 12(Suppl. 4): S146-S148



Twenty-three patients [mean age 49.7 +/- 5.6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO). After a control period of 10 days, NTP was started with 20 mg twice a day and titrated to the maximal dosage of 2 X 40 mg/day. After 1 week of NTP treatment, PRO was added in increasing dosage to a maximal 2 X 100 mg/day. NTP lowered systolic and diastolic blood pressure (BP) significantly (supine BP from 182/119 +/- 19/9 to 157/98 +/- 16/9 mm Hg). After combination with PRO, systolic BP was decreased additionally (supine BP from 157/98 +/- 16/9 to 150/97 +/- 19/9 mm Hg). Plasma norepinephrine (NE) was increased by NTP (from 1.82 +/- 0.78 to 2.38 +/- 1.08 nmol/l, p less than 0.01) and remained elevated during PRO treatment (2.76 +/- 1.10 nmol/l). Plasma renin activity (PRA) showed no significant changes by NTP. Additional effect of PRO on BP correlated significantly with NE and PRA after the NTP period. Plasma epinephrine and dopamine beta-hydroxylase remained unchanged. NTP decreased systemic resistance, calculated from isotope dilution technique (p less than 0.05); after combination with PRO no additional significant changes were registered. Nitrendipine is an effective alternative in so-called therapy-resistant hypertension.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040807903

Download citation: RISBibTeXText

PMID: 2468860

DOI: 10.1097/00005344-198806124-00033


Related references

The effect of 8 weeks treatment with the calcium antagonist felodipine on blood pressure heart rate working capacity plasma renin activity plasma angiotensin ii urinary catecholamines and aldosterone in patients with essential hypertension. British Journal of Clinical Pharmacology 21(6): 633-640, 1986

Blood pressure, heart rate, catecholamines and plasma renin activity following institution and withdrawal of guanfacine treatment in moderate hypertension. British Journal of Clinical Pharmacology 10(Suppl. 1): 109s-114s, 1980

Effects of guanfacin monotherapy on blood pressure heart rate plasma renin activity aldosterone and catecholamines in hypertensive patients with chronic glomerulonephritis. Clinical Pharmacology & Therapeutics 43(3): 278-282, 1988

Blood pressure, renin activity and heart rate changes during propranolol therapy of hypertension. American Journal of Cardiology 40(1): 105-109, 1977

Relationships between blood pressure heart rate and plasma epinephrine norepinephrine angiotensin ii concentrations plasma renin activity during chronic guanfacin therapy in patients with essential arterial hypertension. Acta Cardiologica 40(3): 269-276, 1985

Hemodynamic effect of propranolol therapy in relationship to renin status and plasma catecholamines in primary hypertension. Journal of Clinical Pharmacology 20(1): 20-29, 1980

Labetalol in the treatment of severe essential hypertension: relationship between arterial blood pressure, plasma catecholamines, plasma renin activity, plasma aldosterone and body weight. Acta Medica Scandinavica. Supplementum 625: 59-64, 1979

Hemodynamic indices the blood plasma level of renin and aldosterone in patients with different forms of arterial hypertension treated with the combination of crystepine and propranolol. Kardiologiya 28(1): 81-82, 1988

Effect of naloxone on exercise induced increase in blood pressure heart rate plasma catecholamines plasma renin activity and plasma aldosterone in healthy males. Acta Endocrinologica Suppl. 109(270): 138, 1985

Lack of effect of naloxone in a moderate dosage on the exercise-induced increase in blood pressure, heart rate, plasma catecholamines, plasma renin activity and plasma aldosterone in healthy males. Clinical Science 68(2): 185-191, 1985

The effect of naloxone on blood pressure, heart rate, plasma catecholamines, renin activity and aldosterone following exercise in healthy males. Regulatory Peptides 22(4): 295-302, 1988

Blood catecholamines, plasma renin activity and arterial blood pressure in patients with hypertension. Polskie Archiwum Medycyny Wewnetrznej 58(5): 501-508, 1977

Effects of nifedipine on blood pressure, regional hemodynamics, plasma renin activity and plasma catecholamines in patients with arterial hypertension. Acta Medica Scandinavica. Supplementum 625: 65-67, 1979

Abrupt withdrawal of beta-blocking agents in patients with arterial hypertension. Effect on blood pressure, heart rate and plasma catecholamines and prolactin. European Journal of Clinical Pharmacology 15(3): 215-217, 1979

The effects of clonidine and propranolol, separately and in combination, on blood pressure and plasma renin activity in essential hypertension. Journal of Clinical Pharmacology 18(5-6): 233-240, 1978