+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Norfloxacin and silver-norfloxacin as topical antimicrobial agents: results of in vitro susceptibility testing against bacteria and Candida sp isolated from burn patients



Norfloxacin and silver-norfloxacin as topical antimicrobial agents: results of in vitro susceptibility testing against bacteria and Candida sp isolated from burn patients



Journal of Burn Care and Rehabilitation 7(6): 479-483



Because of its broad spectrum of antibacterial action, Norfloxacin, a new quinoline carboxylic acid compound, was formulated in a topical cream base and tested for activity against a variety of bacteria and yeasts isolated from burn patients. An in vitro agar well diffusion topical susceptibility test was used. The silver salt of Norfloxacin also was tested. For comparative purposes, commonly used topical antibacterial and antifungal preparations were examined as well. No bacterial isolate tested was resistant to the action of Norfloxacin or that of silver-Norfloxacin. Furthermore, all Candida organisms assayed were susceptible to silver-Norfloxacin. All other topical agents tested had some strains of bacteria or yeast, or both, that were resistant to their action. Therefore, Norfloxacin and, particularly, silver-Norfloxacin, warrant further development as topical anti-infective agents for use in treating burn patients.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040820103

Download citation: RISBibTeXText

PMID: 3429479


Related references

Norfloxacin and Silver-Norfloxacin as Topical Antimicrobial Agents. Journal of Burn Care & Rehabilitation 7(6): 479-483, 1986

In vitro susceptibility testing of topical antimicrobial agents used in pediatric burn patients: comparison of two methods. Journal of Burn Care & Rehabilitation 18(5): 406-410, 1997

In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents. Antimicrobial Agents and ChemoTherapy 28(3): 442-445, 1985

Comparison of topical therapeutic effect between silver norfloxacin (Ag-NFL) and silver sulfadiazine (Ag-SD) in treatment of pyocyaneous sepsis in burn rats. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 9(2): 118-20, 159, 1993

Eighteen months of routine topical antimicrobial susceptibility testing of isolates from burn patients: results and conclusions. Journal of Antimicrobial ChemoTherapy 5(4): 455-463, 1979

The MIC/MBC and in vitro killing kinetics of topical antimicrobial agents against Staphylococcus aureus isolated from pediatric burn patients. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 38: 218, 1998

Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit. Transactions of the American Ophthalmological Society 82: 75-91, 1984

Cross resistance to norfloxacin and other antimicrobial agents among clinical isolates of gram negative bacteria. International Journal of Experimental & Clinical Chemotherapy 3(4): 201-205, 1990

In vitro antibacterial activity of norfloxacin compared with eight other antimicrobial agents. European Journal of Clinical Microbiology 2(3): 230-234, 1983

In vitro activities of antimicrobial agents against norfloxacin-resistant MRSA. Zhongguo Kangshengsu Zazhi 19(5): 388-390, 1994

In vitro efficacy of various topical antimicrobial agents in different time periods from contamination to application against 6 multidrug-resistant bacterial strains isolated from burn patients. Burns 40(4): 713-718, 2015

Antimicrobial activity of norfloxacin in enteric and urinary tract infections: combined effect of norfloxacin with aminoglycosides, tetracycline and chloramphenicol. Drugs Under Experimental and Clinical Research 12(4): 319-323, 1986

Determination of norfloxacin, an active dissociation product of silver norfloxacin, in guinea pig plasma and tissue by high performance liquid chromatography with column-switching. Yao Xue Xue Bao 29(7): 539-543, 1994

In-vitro activity of commonly used antifungal agents in the presence of rifampin, polymyxin B and norfloxacin against Candida albicans. Journal of ChemoTherapy 7(6): 525-529, 1995

Antimicrobial susceptibility testing of bacteria isolated from animals: methods for in-vitro susceptibility testing and their suitability with regard to the generation of most useful data for therapeutic applications. Berliner und Munchener Tierarztliche Wochenschrift 116(9/10): 353-361, 2003