EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Oleander poisoning: treatment with digoxin-specific Fab antibody fragments



Oleander poisoning: treatment with digoxin-specific Fab antibody fragments



Annals of Emergency Medicine 17(7): 732-735



A 37-year-old man presented two hours after the ingestion of "a handful" of oleander leaves (probably Nerium oleander) in a suicide attempt. Cardiotoxicity was evidenced by the presence of bradycardia (rate, 30 to 45) with sinoatrial nodal arrest and junctional escape consistent with a cardiac glycoside effect. The patient was treated empirically with a single dose of five vials (200 mg) of digoxin-specific Fab antibody fragments (Digibind). The pretreatment digoxin level was 1.5 ng/mL. After treatment, the patient's rhythm stabilized with residual sinus bradycardia (rate, 56). The patient recovered uneventfully and was discharged on the fifth hospital day to inpatient psychiatric care.

(PDF same-day service: $19.90)

Accession: 040854560

Download citation: RISBibTeXText

PMID: 3382077

DOI: 10.1016/s0196-0644(88)80625-5



Related references

A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments. Turk Kardiyoloji Dernegi Arsivi 43(7): 648-650, 2016

Treatment of life-threatening digoxin poisoning with heterologous digoxin-specific antibody fragments. Deutsche Medizinische Wochenschrift 108(38): 1441-1443, 1983

Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: case report and review of literature. Zeitschrift für Kardiologie 94(12): 817-823, 2005

Use of digoxin-specific antibody fragments in suicidal oleander toxicity. Journal of Toxicology Clinical Toxicology 34(5): 600, 1996

Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. Effect of treatment with digoxin-specific Fab antibody fragment (ovine). American Journal of Clinical Pathology 108(4): 411-416, 1997

Beneficial effect of digoxin-specific Fab antibody fragments in oleander intoxication. Archives of Internal Medicine 155(19): 2121-2125, 1995

The effectiveness of digoxin-specific F(ab')2-antibody fragments in the treatment of digitoxin poisoning: experimental investigations in the cat. European Journal of Clinical Investigation 10(2 Pt 1): 93-97, 1980

Effectiveness of digoxin specific fab' 2 antibody fragments in the treatment of digitoxin poisoning experimental investigations in the cat. European Journal of Clinical Investigation 10(2 PART 1): 93-98, 1980

Use of digoxin-specific antibody fragments (Fab) in the management of digoxin poisoning. Ulster Medical Journal 55(1): 89-92, 1986

Digoxin-specific Fab fragments in the treatment of oleander toxicity in a canine model. Annals of Emergency Medicine 20(10): 1073-1077, 1991

Use of digoxin-specific antibody fragments in treatment of digoxin intoxication in hemodialysis patients. Journal of the American Society of Nephrology 5(3): 469, 1994

Recurrent digoxin overdose and treatment with digoxin-specific Fab antibody fragments. Journal of Emergency Medicine 12(2): 179-185, 1994

Treatment of severe digoxin toxicity with digoxin-specific antibody fragments. Anaesthesia and Intensive Care 15(2): 234-236, 1987

Treatment of digoxin intoxication in a renal failure patient with digoxin-specific antibody fragments and plasmapheresis. American Journal of Nephrology 10(6): 518-521, 1990

Digoxin-specific antibody fragments for the treatment of digoxin intoxication. Clinical Pharmacy 5(10): 826-827, 1986