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Oligomerization of Friend spleen focus-forming virus (SFFV) env glycoproteins

Oligomerization of Friend spleen focus-forming virus (SFFV) env glycoproteins

Virology 177(1): 312-316

The glycoprotein gp55 and its processed form gp65, which are encoded by the env gene of Friend spleen focus-forming virus (SFFV), have been implicated in the initiation of the murine acute erythroleukemia induced by Friend virus (FV). Analyses of these glycoproteins by chemical crosslinking and nonreducing/reducing two-dimensional electrophoresis showed that both gp55 and gp65 exist as monomer and disulfide-bonded dimer and trimer. These oligomers could be detected in various FV-infected erythroleukemia cell lines, as well as in the spleen cells of FV-induced erythroleukemic mice, suggesting that oligomerization is an intrinsic feature of SFFV env glycoproteins.

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Accession: 040855103

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PMID: 2162106

DOI: 10.1016/0042-6822(90)90485-a

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