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Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes

Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes

Arzneimittel-Forschung 25(4): 571-576

ISSN/ISBN: 0004-4172

PMID: 1098677

Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.

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Accession: 040955012

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