EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Pharmacodynamics of allapinin and its possible adverse effects


Pharmacodynamics of allapinin and its possible adverse effects



Kardiologiia 29(7): 29-32



ISSN/ISBN: 0022-9040

PMID: 2478747

Allapinine (Class IC), a new antiarrhythmic agent, was studied in 76 patients with premature contraction. Allapinine was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day. Larger-dose allapinine produced adverse effects, its lower dosage had no antiarrhythmic effect. The drug failed to affect blood pressure, heart rate, QT interval length. The PQ interval and QRS complex were increased. The side effects were dose-dependent. There was a risk of the drug's arrhythmogenic effect.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040955788

Download citation: RISBibTeXText

Related references

Pharmacodynamics and the effectiveness of allapinin in patients with arrhythmia. Klinicheskaia Meditsina 66(10): 52-55, 1988

Pharmacokinetics and pharmacodynamics of the new Russian anti-arrhythmia drug allapinin. Kardiologiia 29(1): 32-36, 1989

The pharmacokinetics and pharmacodynamics of the new Soviet anti-arrhythmia preparation allapinin. Farmakologiia i Toksikologiia 51(5): 47-49, 1988

Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenetics and Genomics 21(7): 440-446, 2011

GW280430A: pharmacodynamics and potential adverse effects. Anesthesiology 102(4): 861, 2005

Doxorubicin pathways:pharmacodynamics and adverse effects. Pharmacogenet Genomics 21(7): 440-446, 2012

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects. Basic and Clinical Pharmacology and Toxicology 124(3): 321-329, 2019

Pharmacodynamics, clinical indications, and adverse effects of heparin. Journal of Clinical Pharmacology 32(7): 584-596, 1992

Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects. Journal of Clinical Pharmacology 32(3): 196-209, 1992

Pharmacokinetics and pharmacodynamics: interactions and adverse effects. Comparison with other echinocandins. Enfermedades Infecciosas y Microbiologia Clinica 26 Suppl. 14: 14-20, 2008

Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents. Terapevticheskii Arkhiv 53(7): 142-151, 1981

Pharmacogenetics of quetiapine in healthy volunteers: association with pharmacokinetics, pharmacodynamics, and adverse effects. International Clinical Psychopharmacology 30(2): 82-88, 2015

Pharmacodynamics and clinical adverse effects of mivacurium. The effect of oral premedication with H1/H2 antagonists. Der Anaesthesist 42(9): 592-596, 1993

In-silico pharmacodynamics: correlation of adverse effects of H2-antihistamines with histamine N-methyl transferase binding potential. Applied Bioinformatics 5(3): 141-150, 2006

Tramadol hydrochloride: pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomedicine and PharmacoTherapy 70: 234-238, 2015