+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pharmacokinetic studies of a new oral cephem T-2588. Pharmacokinetics in gastrectomized volunteers and the renal excretory system in healthy volunteers



Pharmacokinetic studies of a new oral cephem T-2588. Pharmacokinetics in gastrectomized volunteers and the renal excretory system in healthy volunteers



Japanese Journal of Antibiotics 39(10): 2701-2709



According to the result of the pharmacokinetic examination of T-2588 (esterified prodrug of T-2525) administered to adult male volunteers who have undergone gastrectomy, it appears that the absorption of T-2588 is delayed in the hypoacidity or the anacidity and also the excretion ratio of T-2525A (an inactive metabolite of T-2525) showed a tendency to become higher in these subjects. Again, according to the result of the pharmacokinetic examination of T-2588 when it was administered together with probenecid to normal healthy volunteers, it appears that the T-2525 is excreted from the kidneys not only into the glomerular filtration but also partly through renal tubules.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040956602

Download citation: RISBibTeXText

PMID: 3806955


Related references

Pharmacokinetics of micafungin in healthy volunteers, volunteers with moderate liver disease, and volunteers with renal dysfunction. Journal of Clinical Pharmacology 45(10): 1145-1152, 2005

Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers: an interethnic comparative study between Japanese and European volunteers. Journal of Clinical Pharmacology 38(12): 1129-1136, 2001

Pharmacokinetics and safety of e 1077 a novel parenteral cephem antibiotics in healthy volunteers. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 31: 240, 1991

Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers. Cpt: Pharmacometrics and Systems Pharmacology 4(8): 454-464, 2015

Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy male and female volunteers An interethnic comparative study of Japanese and Caucasian volunteers. British Journal of Clinical Pharmacology 45(2): 211P, 1998

Pharmacokinetic and pharmacodynamic studies after oral administration of budesonide in healthy volunteers. Gastroenterology 106(4 SUPPL ): A737, 1994

Pharmacokinetics in healthy volunteers and patients with impaired renal function after oral cefotiam hexetil. Acta Therapeutica 15(4): 337-354, 1989

Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses. Antimicrobial Agents and ChemoTherapy 52(4): 1391-1395, 2008

Pharmacokinetics of oral cefcanel daloxate hydrochloride in healthy volunteers and patients with various degrees of impaired renal function. Journal of Antimicrobial ChemoTherapy 33(2): 281-288, 1994

Pharmacokinetics of oral talinolol following a single dose and during steady state in patients with chronic renal failure and healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 39(2): 61-66, 2001

Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function. European Journal of Clinical Pharmacology 39(6): 573-576, 1990

Phase I pharmacokinetic and pharmacodynamic studies of G-CSF in patients with renal or liver impairment compared to healthy volunteers. British Journal of Haematology 93(SUPPL 2): 277, 1996

Pharmacokinetics of the Oral Selective CXCR2 Antagonist AZD5069: A Summary of Eight Phase I Studies in Healthy Volunteers. Drugs in R&d 18(2): 149-159, 2018

A pharmacokinetics evaluation of a new, low-volume, oral sulfate colon cleansing preparation in patients with renal or hepatic impairment and healthy volunteers. Journal of Clinical Pharmacology 50(3): 350-354, 2010

Multiple dose pharmacokinetic and bioavailability studies of oral sustained release and conventional formulations of naproxen in healthy volunteers. Zhongguo Yiyao Gongye Zazhi 30(3): 130-132, 1999