+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Population cytogenetics of folate-sensitive fragile sites. I. Common fragile sites



Population cytogenetics of folate-sensitive fragile sites. I. Common fragile sites



Human Genetics 80(4): 344-348



The location and frequency of folate-sensitive common fragile sites (CFS) were studied in three populations: (1) 111 mentally retarded children of school age, (2) 240 mentally subnormal children attending special schools, and (3) 85 healthy children attending normal schools. Common fragile sites were found at 54 chromosomal bands including also the band Xq27, where gaps and breaks were detected in 4% of the children. The most frequent CFS were FRA3B (at 3p14.2), FRA6E (at 6q26), and FRA16D (at 16q23) seen in 73%, 65%, and 58% of the individuals totally studied. The frequencies of CFS-positive individuals did not differ among the populations. The variation found in the distribution of CFS among the populations was primarily assumed to be due to sampling differences and study method. The rate of expression of the most frequent CFS varied significantly among the individuals, seeming to suggest that polymorphism exists at those CFS.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041007107

Download citation: RISBibTeXText

PMID: 3198111


Related references

Population cytogenetics of folate-sensitive fragile sites. II. Autosomal rare fragile sites. Human Genetics 82(1): 3-8, 1989

Heritable fragile sites on human chromosomes 10. new folate sensitive fragile sites 6p23 9p21 9q32 and 11q23. American Journal of Human Genetics 35(3): 432-437, 1983

Folate sensitive chromosomal fragile sites in dogs potential animal model for correlating heritable fragile sites and a predisposition to malignancy. American Journal of Human Genetics 43(3 SUPPL): A34, 1988

How common are common fragile sites: Variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus). Human Genetics 100(2): 182-188, 1997

Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites. American Journal of Human Genetics 34(3): 452-458, 1982

Expression of fudr induced fragile fra sites in a newborn nb and a mentally retarded mr population phenotypic effects and possible association of rare autosomal folate sensitive fra sites and idiopathic mr. American Journal of Human Genetics 43(3 SUPPL): A43, 1988

The value of folate sensitive fragile sites in detecting false negative fragile x prenatal cytogenetic results in amniotic fluid cell cultures. American Journal of Human Genetics 39(3 SUPPL): A269, 1986

Heritable fragile sites on human chromosomes. IX. Population cytogenetics and segregation analysis of the BrdU-requiring fragile site at 10q25. American Journal of Human Genetics 34(5): 753-756, 1982

Folate sensitive common fragile sites in chromosomes of the domestic pig (Sus scrofa). Research in Veterinary Science 55(2): 231-235, 1993

Neither age nor sex influence the expression of folate sensitive common fragile sites on human chromosomes. Human Genetics 86(1): 76-78, 1990

How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites. Cytogenetic and Genome Research 101(1): 8-16, 2003

Interstitial telomeric sequences in human chromosomes cluster with common fragile sites, mutagen sensitive sites, viral integration sites, cancer breakpoints, proto-oncogenes and breakpoint involved in primate evolution. American Journal of Human Genetics 55(3 SUPPL ): A253, 1994

Possible association of rare autosomal folate sensitive fragile sites and idiopathic mental retardation a blind controlled population study. Clinical Genetics 38(4): 241-256, 1990

Population cytogenetics of autosomal fragile sites. Clinical Genetics 31(1): 61-62, 1987

Population cytogenetics of aphidicolin-induced fragile sites. Human Genetics 89(5): 543-547, 1992