+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis



Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis



Immunology 74(3): 539-545



The inflammatory response in the central nervous system (CNS) of rats with differing susceptibility to demyelinating encephalitis induced by coronavirus MHV4 was characterized. Topographical maps showing the arrangement of infiltrating lymphocyte subsets in virus-infected tissue were developed by digital-image processing of immunohistologically stained CNS sections. The kinetics of the inflammatory process was evaluated by flow-cytometry on lymphocytes isolated from the CNS. Cumulative data obtained with these two techniques demonstrated the following features. In susceptible Lewis (LE) rats, viral antigens were disseminated throughout the CNS, including spinal cord. Onset as well as recovery from neurological disease was associated with a steep rise of infiltrating CD8+ T cells, which localized in close contact to virus-infected cells. Accompanying convalescence was a slight increase in B(OX33+) cells in the CNS and the accumulation of immunoglobulin-containing cells in the centre of virus-infected areas. In clinically resistant Brown Norway (BN) rats, virus-infected cells were mainly restricted to small periventricular foci and the extent of lymphocyte infiltration was never as high as that found at any time during the course of infection in LE rats. There were striking differences in the CD8+ T-cell population compared to LE rats. Cells of this phenotype were identified in virus-affected areas of BN rats only early after infection, and their infiltration profile revealed much lower quantities than in the CNS of susceptible LE rats. Although the population dynamics of B(OX33+) lymphocytes were comparable in BN and LE rats, as determined by flow-cytometry, less immunoglobulin-containing B cells were detected in virus-infected areas of BN rats.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041007180

Download citation: RISBibTeXText

PMID: 1663079


Related references

The pathogenic role of virus-specific antibody-secreting cells in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis. Immunology 74(3): 533-538, 1991

Characterization of CD4+T-cells infiltrating the central nervous system of rats with coronavirus JHM-induced demyelinating encephalomyelitis. Immunobiology 189(1-2): 221, 1993

Phenotypic and functional characterization of CD8+ T lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis. Journal of Neurovirology 1(5-6): 340-348, 1995

Expression of interleukin mRNA in lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis. Immunobiology 189(1-2): 215, 1993

Characterization of the inflammatory response in the central nervous system of rats with different susceptability to coronavirus mhv4 induced encephalitis. Journal of Neuroimmunology (Suppl. 1): 107, 1991

Cervical lymphoid tissue but not the central nervous system supports proliferation of virus-specific T lymphocytes during coronavirus-induced encephalitis in rats. Journal Of Neuroimmunology. 53(1): 73-81, 1994

Population kinetics of lymphocyte subsets in the CNS of rats with corona virus-induced demyelinating encephalomyelitis. Immunobiology 189(1-2): 216-217, 1993

The role of T-lymphocyte subsets in susceptibility and resistance to induction of autoimmunity in the central nervous system. Glas. Srpska Akademija Nauka i Umetnosti. Odeljenje Medicinskih Nauka 1994(44): 35-43, 1994

The role of CD+T-lymphocytes in coronavirus JHM-induced demyelinating encephalitis of rats. Immunobiology 189(1-2): 220, 1993

Environmentally induced differences in susceptibility of rats to central nervous system stimulants and central nervous system depressants evidence against a unitary explanation. Psychopharmacology 61(3): 299-308, 1979

On the role of different lymphocyte subpopulations in the course of coronavirus MHV IV (JHM)-induced encephalitis in Lewis rats. Advances in Experimental Medicine and Biology 342: 425-430, 1993

Ultrastructure of 6-aminonicotinamide (6-AN)-induced lesions in the central nervous system of rats. II. Alterations of the nervous susceptibility with aging. Acta Neuropathologica 49(1): 19-27, 1980

Ultrastructure of 6 amino nicotinamide induced lesions in the central nervous system of rats 2. alterations of the nervous susceptibility with aging. Acta Neuropathologica 49(1): 19-28, 1980

Modulation of acute coronavirus-induced encephalomyelitis in -irradiated rats by transfer of naive lymphocyte subsets before infection. Journal of Neurovirology 5(3): 249-257, 1999

Observations on the distribution of canine distemper virus in the central nervous system of dogs with demyelinating encephalitis. Acta Neuropathologica 40(3): 233-236, 1977