Potential genotoxic effects of cytostatics in occupationally-exposed persons

Brumen, V.; Horvat, D.

Arhiv Za Higijenu Rada i Toksikologiju 43(4): 313-319

1992


ISSN/ISBN: 0004-1254
PMID: 1297307
Accession: 041024933

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Abstract
The aim of the study was to determine possible mutagenic implications of occupational exposure to cytostatic agents. Twenty-one nurses handling antineoplastic drugs and a matching control group were examined. The conventional method for testing chemical mutagens, that of sister chromatid exchanges, SCE, was used. Although the results obtained in the exposed group did not significantly differ from those obtained for the controls, wide ranges of SCE values observed among the medical personnel handling cytostatic drugs confirm the suspicion of the genotoxic effect of those agents.