+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Presence of clusters of Langerhans cells and lymphoid cells in the peritumoral infiltrate of a case of basal cell naevus syndrome. Ultrastructural study

Presence of clusters of Langerhans cells and lymphoid cells in the peritumoral infiltrate of a case of basal cell naevus syndrome. Ultrastructural study

Annales de Dermatologie et de Venereologie 106(3): 237-240

A case of naevoid basal cell carcinoma syndrome with clusters of Langerhans' and lymphoid cells in the inflammatory peritumoral infiltrate, is reported. Electron microscopy shows intercellular contacts between eight to ten lymphoid cells and a single Langerhans' cell. These contacts occur over limited areas of the cell membranes by means of zones of high electron density on the outer edge of the cytoplasm. The functional significance of this finding is discussed, bearing in mind that recent observations have established certain analogies between Langerhans' and interdigitating reticulum cells. The latter might, within the thymus-dependent region of the lymph nodes, contribute to the formation of a micro-environment favourable to certain immunological activities of T-lymphocyte populations.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 041048551

Download citation: RISBibTeXText

PMID: 485022

Related references

Differentiation of interdigitating reticulum cells and Langerhans cells in the human skin with T-lymphoid infiltrate. An immunocytochemical and ultrastructural study. Archives of Histology and Cytology 52(4): 361-372, 1989

Immunohistochemical study of epidermal Langerhans cells and dermal dendritic cells in benign and malignant skin lesions characterized by a dermal lymphoid infiltrate consisting either of B-cells or T-cells. Virchows Archiv. A Pathological Anatomy and Histopathology 411(4): 337-343, 1987

Interdigitating cells in the peritumoral infiltrate of laryngeal carcinomas: an immunocytochemical and ultrastructural study. Orl; Journal for Oto-Rhino-Laryngology and its Related Specialties 53(6): 349-356, 1991

Non-lymphoid accessory cells in the cutaneous infiltrate of B cell lymphomas. An immunohistochemical and ultrastructural study. British Journal of Dermatology 118(3): 353-362, 1988

Histologic, immunofluorescence and ultrastructural study of mast cells infiltrate in basal cell carcinoma. Journal of Investigative Dermatology 100(4): 548, 1993

CD1a+ Langerhans cells in the peritumoral epidermis of basal cell carcinoma. Actas Dermo-Sifiliograficas 100(8): 700-705, 2009

Actinoreticulosis occuring during a late skin porphyria: optic and ultrastructural study of a case (presence of Langerhans granules in the histiocytes of the infiltrate. Archives d'Anatomie Pathologique 23(2): 145-150, 1975

An absence of human leukocyte antigen-DR and a decreased expression of beta 2-microglobulin on tumor cells of basal cell carcinoma: no influence on the peritumoral immune infiltrate. Journal of the American Academy of Dermatology 20(1): 47-52, 1989

Langerhans cells acquire a CD8+ lymphoid dendritic cell phenotype upon CD40 ligation Evidence for the lymphoid lineage of Langerhans cells. Journal of Investigative Dermatology 114(1): 223, 2000

HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters. Journal of Immunology 172(4): 2219-2224, 2004

Studies on the radiosensitivity of cells from patients with basal cell naevus syndrome. American Journal of Human Genetics 35(1): 58-66, 1983

Morphologic and morphometric study of the two main cell lineages involved in mycosis fungoides: the lymphoid cells and the Langerhans cells. Ultrastructural Pathology 3(2): 119-136, 1982

An ultrastructural study of Langerhans cells crossing the basal complex in oral lichen planus. Archives of Oral Biology 22(10-11): 629-631, 1977

Expression of HLA-DR molecules by keratinocytes, and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques. Journal of Experimental Medicine 164(4): 1013-1028, 1986

A novel cell surface protein expressed by murine epithelial cells, Langerhans cells and lymphoid dendritic cells. Journal of Investigative Dermatology 102(4): 628, 1994