EurekaMag
+ Translate
+ Most Popular
Sobre os generos Lopadusa Stal e Bothrocoris Mayr (Hemiptera, Pentatomidae, Pentatomini)
RFEF pilot plant for inactivation of Escherichia coli in apple juice
Calpionella alpina Lorenz als "Leitfossil"
Sooretama: The Atlantic Rain Forest of Brazil. Francis Dov Por
Novel approaches in myeloma therapy
Preliminary Notes on the Study of Mitochondria During the 1st Stages of the Destruction of Cadavers
A preliminary study of the biology of lichee stink bug, Tessaratoma papulosa Drury, and its control
The status of the Sabu Island python - Die Situation des Savu-Pythons
Randomised trial of intravenous immunoglobulin as prophylaxis against infection in plateau-phase multiple myeloma. the UK Group for Immunoglobulin Replacement therapy in Multiple Myeloma
Conflicts between children
Clinical presentations in neuropsychiatry
Method of suturing a perforated ulcer of the stomach and duodenum
Identification of mechanical asphyxiation in cases of attempted masking of the homicide
Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig
Is it warm? Is it real? Or just low spatial frequency?
Additions and corrections to the list of Korean Heteroptera
Factors contributing to the maintenance of oligotrophy in an alpine glacial moraine lake (Wallowa lake) in Northeast Oregon
Classification, paleoecology, and biostratigraphy of crinoids from the Stull Shale (Late Pennsylvanian) of Nebraska, Kansas, and Iowa
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Neue Formen der Bauchsammler aus Turkmenien (Hymenoptera, Apoidea)
Atypische Hühnerpest und Newcastle-Krankheit. Ein Identifizierungsversuch
Parasitellus fucorum in the debris of Apis mellifera - a risk of confusion with Tropilaelaps spp
Applying the Technology Acceptance Model to the introduction of healthcare information systems
Ein akarologischer Nachruf für den "Roland"
Mutation research on crop plants in Argentina

Pretreatment serum levels of C-reactive protein, alpha 1-antitrypsin, haptoglobin, alpha 1-acid glycoprotein and tissue polypeptide antigen in cervical carcinoma


Pretreatment serum levels of C-reactive protein, alpha 1-antitrypsin, haptoglobin, alpha 1-acid glycoprotein and tissue polypeptide antigen in cervical carcinoma



European Journal of Gynaecological Oncology 12(5): 375-383



ISSN/ISBN: 0392-2936

PMID: 1717278

In order to evaluate the potentially additive information of some acute phase reactants to that provided by a general tumour marker, pretreatment concentrations of C-reactive protein, alpha 1-antitrypsin, haptoglobin, alpha 1-acid glycoprotein and tissue polypeptide antigen were determined in serum from healthy women, patients with dysplasia/or carcinoma in situ and patients with primary cervical carcinoma. Specificity varied from 95-100% and sensitivity from 16-29%. A correlation with clinical stage was found for all analytes except for alpha 1-antitrypsin. The latter was the most frequently elevated analyte in early Stages (11/43 in Stage Ib/IIa) and uniquely elevated in 7 cancer patients. Although tissue polypeptide antigen predominantly signaled in advanced stages, 3 women in early stages had elevated tissue polypeptide antigen levels. One of these women died and she was also the only woman with raised alpha 1-antitrypsin who died. It is discussed whether elevated tissue polypeptide levels might represent an unfavourable sign for the individual and if alpha 1-antitrypsin is a favourable sign in early stages of cervical carcinoma. C-reactive protein results were obscured in early stages of disease by the presence of intercurrent illness and the results were regarded as inconclusive. Haptoglobin and alpha 1-acid glycoprotein concentrations provided no additional information to serum alpha 1-antitrypsin levels. However, haptoglobin was elevated in 64% (36/56) of the women with dysplasia/carcinoma in situ of the cervix uteri.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041053183

Download citation: RISBibTeXText

Related references

Chronic bronchitis: concentration of alpha-1-antitrypsin (alpha-1-Pi), alpha-2-microglobulin (alpha-2-Pi), C-reactive protein, alpha-1 acid glycoprotein, immunoglobulin A (IgA) and secretory IgA in sputum and serum. Praxis und Klinik der Pneumologie 40(6): 266-273, 1986

Intraindividual variation of total protein transferrin haptoglobin acid alpha 1 glycoprotein alpha 2 macroglobulin properdin factor b complement c 3 complement c 4 iga igg igm alpha 1 antitrypsin and ceruloplasmin in the fasting serum of healthy males. Aerztliche Laboratorium 32(12): 286-292, 1986

Behavior of the immunoglobulins (IgA, IgG, IgM), of complement (C'3) and other serum proteins (acid alpha 1-glycoprotein, alpha-1-antitrypsin, alpha-2-macroglobulin, haptoglobin, ceruloplasmin, transferrin) in cases of viral hepatitis. Giornale di Batteriologia Virologia Ed Immunologia Ed Annali Dell'ospedale Maria Vittoria di Torino 65(5): 182-189, 1972

A comparison of serum mucoprotein with serum alpha 1 acid glycoprotein, haptoglobin, and alpha 1 antitrypsin assays in monitoring inflammatory bowel disease. Clinica Chimica Acta; International Journal of Clinical Chemistry 188(1): 59-69, 1990

Electroimmunodiffusion of cerebrospinal fluid proteins. Determination of prealbumin, albumin, alpha 1-antitrypsin, alpha 1-acid glycoprotein, alpha 2-haptoglobin, alpha 2-macroglobulin, and transferrin. Clinica Chimica Acta; International Journal of Clinical Chemistry 30(1): 73-82, 1970

Clinical Value of Pretreatment Serum Cyfra 21-1, Tissue Polypeptide Antigen, and Squamous Cell Carcinoma Antigen Levels in Patients with Cervical Cancer. Cancer 76(5): 807-813, 1995

Behavior of immunoglobulins. (IgA, IgG, IgM), of the C'3 and of the alpha globulins (alpha-1-antitrypsin, alpha-1-macroglobulin, haptoglobin, alpha-1-glyco-protein acid) in the rheumatic disease in infancy. Minerva Pediatrica 23(19): 861-867, 1971

Prospective study of the prognostic value of C reactive protein, alpha 1-antitrypsin and alpha 1-acid glycoprotein in acute pancreatitis. Revista Espanola de Enfermedades Digestivas: Organo Oficial de la Sociedad Espanola de Patologia Digestiva 79(5): 337-340, 1991

Comparative studies of bronchial secretions from children with chronic nontuberculous lung diseases iii. estimations of lysozyme transferrin alpha 1 antitrypsin alpha 2 macroglobulin haptoglobin alpha 1 acid glycoprotein. Allergie und Immunologie 34(2): 99-108, 1988

Comparative studies of bronchial secretions in children with chronic, nontuberculous lung diseases. 3. The detection of lysozyme, transferrin, alpha 1-antitrypsin, alpha 2-macroglobulin, haptoglobin and alpha 1-acid glycoprotein. Allergie und Immunologie 34(2): 99-108, 1988

Multicenter evaluation of five new turbidimetric assays for alpha-1-acid glycoprotein, alpha-1-antitrypsin, ceruloplasmin, haptoglobin and prealbumin. Clinical Chemistry 42(6 Part 2): S121, 1996

The acute phase response of acid soluble glycoprotein, alpha(1)-acid glycoprotein, ceruloplasmin, haptoglobin and C-reactive protein, in the pig. Veterinary Immunology and Immunopathology 51(3-4): 377-385, 1996

Acute phase proteins in "small for dates" babies. II. Haptoglobin, transferrin, alpha-1-feto protein, alpha-1-acid glycoprotein and caeruloplasmin levels. African Journal of Medicine and Medical Sciences 21(1): 55-59, 1992

Evaluation of immunoturbidimetric assays for alpha-1-acid glycoprotein, alpha-1-antitrypsin, beta 2-microglobulin, haptoglobin, microalbumin, and myoglobin on the Olympus AU600 chemistry immuno analyzer. Clinical Chemistry 45(6 Part 2): A52-A53, 1999

Changes in serum alpha 1 antitrypsin, alpha1 acid glycoprotein and beta 2 glycoprotein I in patients with malignant hepatocellular carcinoma. Cancer 43(2): 596-604, 1979