Prevalence of natural infection with simian immunodeficiency virus and simian T-cell leukemia virus type i in a breeding colony of sooty mangabey monkeys

Fultz, P.N.; Gordon, T.P.; Anderson, D.C.; McClure, H.M.

Aids 4(7): 619-625

1990


ISSN/ISBN: 0269-9370
PMID: 2168716
DOI: 10.1097/00002030-199007000-00002
Accession: 041055421

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Abstract
The seroprevalence of antibodies to simian immunodeficiency virus (SIVsmm) and simian T-cell leukemia virus type I (STLV-I) in a captive breeding colony of sooty mangabey monkeys was determined, and infection by SIVsmm was confirmed in all cases by virus isolation. Among 138 animals tested, 57 and 33% were infected with SIVsmm and STLV-I, respectively. While the proportion of female mangabeys (66%) differed significantly (P less than 0.01) from the proportion of male mangabeys (42%) infected with SIVsmm, the proportions of males and females infected with STLV-I were similar, suggesting independent transmission of the two viruses. Among mangabeys less than 1 year old, none were infected with STLV-I and only five of 27 mangabeys, all of which were at least 6 months old when first tested, were infected with SIVsmm. The data document that natural infection of sooty mangabey monkeys with SIVsmm or in association with STLV-I infection does not result in increased disease or mortality, and that transmission of both SIVsmm and STLV-I appears to occur primarily through sexual activity.