+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic relevance of DNA ploidy and proliferative activity in urothelial carcinoma of the renal pelvis and ureter. A study on a follow-up period of 6 years



Prognostic relevance of DNA ploidy and proliferative activity in urothelial carcinoma of the renal pelvis and ureter. A study on a follow-up period of 6 years



Urologia Internationalis 47(1): 7-11



In 55 patients with urothelial carcinoma of the renal pelvis or ureter, the ploidy, the DNA heterogeneity and the counts of cell cycle phases in the tumor were examined by means of single-cell DNA cytophotometry in order to find more prognostic factors than those already known (stage and grade). Follow-up periods ranged from 1 to 6 years. At the time of first diagnosis, 42 (76%) of the patients had tumors of the renal pelvis, 13 (24%) of them had ureteral tumors. 23 (42%) patients were in stage pT 1 N 0, 15 (27%) in stage pT 2 N 0, 12 (22%) in stage pT 3 N 0, and 5 (9%) were in stage pT 3 N+. The histological malignancy grade most frequently seen in the patients examined--i.e. in 51% of cases--was malignancy grade II. 25% of the patients had grade III tumors whereas only 24% had grade I tumors. With malignancy grade I, DNA cytophotometry showed DNA frequency peaks to be in the diploid range while tumors with malignancy grade II showed heterogenous DNA patterns. 71% of the patients with malignancy grade III showed aneuploid DNA values; 29% of them had polyploid DNA values. For malignancy grades II and III, the proliferation rate of the tumor cells was statistically significantly higher than for malignancy grade I. The determination of tumor heterogeneity and tumor cell proliferation by means of DNA cytophotometry gives valuable clues regarding prognosis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041088631

Download citation: RISBibTeXText

PMID: 1871915


Related references

Prognostic relevance of dna ploidy and proliferative activity in urothelial carcinoma of the renal pelvis and ureter a study on a follow up of six years. Journal of Urology 143(4 SUPPL): 326A, 1990

Prognostic Relevance of Dna Ploidy and Proliferative Activity in Urothelial Carcinoma of the Renal Pelvis and Ureter. Urologia Internationalis 47(1): 7-11, 1991

Transitional cell carcinoma of the renal pelvis and ureter prognostic relevance of nuclear deoxyribonucleic acid ploidy studies by slide cytometry an 8 year survival time study. Journal of Urology 148(1): 31-37, 1992

Transitional Cell Carcinoma of the Renal Pelvis and Ureter: Prognostic Relevance of Nuclear Deoxyribonucleic Acid Ploidy Studied by Slide Cytometry: An 8-Year Survival Time Study. The Journal of Urology 148(1): 31-37, 1992

Prognostic relevance of ploidy and proliferative activity of renal cell carcinoma. European Urology 15(3-4): 271-276, 1988

The prognostic significance of DNA ploidy pattern in transitional cell cancer of the renal pelvis and ureter: continuing follow-up. European Urology 21 Suppl 1: 48-50, 1992

Apoptosis in transitional cell carcinoma of the renal pelvis and ureter: Association with proliferative activity bcl-2 expression and prognosis. Journal of Urology 158(3 PART 1): 750-753, 1997

Multicentric small cell neuroendocrine neoplasm of the renal pelvis and ureter with concomitant focal high-grade urothelial carcinoma of the ureter: A case report. Indian Journal of Urology 24(4): 571-574, 2009

Inverted urothelial papilloma: Is ploidy, MIB-1 proliferative activity, or p53 protein accumulation predictive of urothelial carcinoma?. Cancer 88(3): 632-636, Feb 1, 2000

A clinicopathological evaluation of prognostic factors of urothelial tumors of the renal pelvis and ureter. Hinyokika Kiyo. Acta Urologica Japonica 47(4): 237-240, 2001

Prognostic significance of Ki-67 labeling index in urothelial tumors of the renal pelvis and ureter. Journal of Urology 155(6): 1877-1881, 1996

Bilateral renal cell carcinoma and concomitant urothelial carcinoma of the renal pelvis and ureter: case report. Lijecnicki Vjesnik 129(3-4): 70-73, 2007

Urothelial carcinoma cancers of the bladder ureter and renal pelvis. Tanagho, E A And J W Mcaninich (Ed ) Smith's General Urology, Thirteenth Edition Xviii+743p Appleton And Lange: Norwalk, Connecticut, Usa; Prentice Hall International (Uk) Ltd : London, England, Uk Illus Paper 341-358, 1992

Urothelial carcinoma "nested variant" of renal pelvis and ureter. Urology 69(4): 778.E15-7, 2007

Ureteroscopic treatment of urothelial carcinoma of the ureter and renal pelvis. Journal of Urology 148(2 Pt 1): 275-277, 1992