Proteolytic destruction of a hemorrhagic toxin from the venom of the habu (Trimeresurus flavoviridis)

Omori-Satoh, T.; Sadahiro, S.; Kondo, S.

Japanese Journal of Medical Science and Biology 38(3): 147-150


ISSN/ISBN: 0021-5112
PMID: 3906206
Accession: 041112874

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The major hemorrhagic principle (HR1B) in the venom of Habu (Trimeresurus flavoviridis), a crotalid, was found to be easily inactivated and hydrolyzed by a commercial protease (Nagarse). The ability of the hydrolysate to produce the toxin-neutralizing antibody has been shown to be comparable to or superior to those of two formol toxoids used as the controls, suggesting that inactivation of HR1B by the protease provides a new method for the preparation of Habu toxoid.