Section 42
Chapter 41,135

Purification and characterization of a new heat-stable enterotoxin produced by Vibrio cholerae non-O1 serogroup Hakata

Arita, M.; Honda, T.; Miwatani, T.; Ohmori, K.; Takao, T.; Shimonishi, Y.

Infection and Immunity 59(6): 2186-2188


ISSN/ISBN: 0019-9567
PMID: 2037379
Accession: 041134487

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The possible production of a heat-stable enterotoxin (Vc-H-ST) by Vibrio cholerae non-O1 serogroup Hakata was investigated, and the purified Vc-H-ST was characterized. It has a unique amino acid sequence, LIDCCEICCNPACFGCLN. This sequence is quite similar to that of the heat-stable enterotoxin (NAG-ST) produced by V. cholerae non-O1 except for one amino acid (leucine) residue excess at the N terminus. Other characteristics, including biological activity, are compatible with those of NAG-ST.

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