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Quantitative bacteriological studies in experimentally infected laboratory animals. 4. Effect of activated and inactivated immunomodulators on experimental Listeria monocytogenes infections



Quantitative bacteriological studies in experimentally infected laboratory animals. 4. Effect of activated and inactivated immunomodulators on experimental Listeria monocytogenes infections



Archiv für Experimentelle Veterinarmedizin 42(1): 83-91



Intraperitioneal application of an avirulent Salmonella dublin strain significantly increased the defence capacity of mice to L. monocytogenes infection experimentally induced one, four, and seven days after the above application. It was thus possible experimentally to reproduce a so called early protective phase also recordable from farm animals which had received activated bacterial vaccines. That protective phase was with high probability primarily attributable to activation of macrophage functions. An inactivated immune modulator (cryoprecipitate of human plasma fraction) was used for comparison but was found to have a negative impact upon defence mechanisms against Listeria. Comparison between experimental and control animals for mortality rates, average survival periods, and organ bacterial counts was used as the criterion for assessment of immune modulation.

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Accession: 041149212

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PMID: 3369916


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