+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Rabbit cardiomyopathy associated with a virus antigenically related to human coronavirus strain 229E



Rabbit cardiomyopathy associated with a virus antigenically related to human coronavirus strain 229E



American Journal of Pathology 95(3): 709-729



A new disease of rabbits is described. Following an acute febrile course, animals die or recover by the 11th day postinoculation. The characteristic pathologic finding is multifocal myocardial degeneration and necrosis. The disease can be transmitted by various routes with tissue filtrates or with infectious sera diluted to 10(-6) and passed through 0.1 micron filters. Virus particles with morphologic features characteristic of a coronavirus are present in infectious but not in normal rabbit serums. The antigen(s) in the infectious serums cross-reacts with the 229E and the OC43 strains of human coronavirus. Antigen cross-reacting with the 229E virus is detectable by immunofluorescent staining in frozen sections of heart tissue from sick but not from healthy animals. Animals surviving infection seroconvert to coronavirus specificity, as demonstrated by the presence in convalescent serums of antibody capable of reacting with the 339E virus. Susceptibility to infection has not been demonstrated in mice, hamsters, or guinea pigs, and the virus was not adapted for growth in tissue culture. It is uncertain whether the agent is a natural pathogen of rabbits or a coronavirus contaminant from another species, possibly human. The name rabbit infectious cardiomyopathy is suggested for this disease.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041156479

Download citation: RISBibTeXText

PMID: 222151


Related references

Oligo nucleotide fingerprints of antigenically related bovine coronavirus mebus strain and human coronavirus oc 43. Abstracts Of The Annual Meeting Of The American Society For Microbiology: Stract T69, 1982

Serological relationships of the subcomponents of human coronavirus strain 229E and mouse hepatitis virus strain 3. Journal of General Virology 58(Pt 2): 449-452, 1982

Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus. Journal of General Virology 74: 1795-1804, 1993

Coronavirus isolates SK and SD from multiple sclerosis patients are serologically related to murine coronaviruses A59 and JHM and human coronavirus OC43, but not to human coronavirus 229E. Journal of Virology 38(1): 231-238, 1981

Antigenic studies on coronavirus 1. identification of the structural antigens of human coronavirus strain 229e. Canadian Journal of Microbiology 27(3): 334-342, 1981

Identification and characterization of a novel alpaca respiratory coronavirus most closely related to the human coronavirus 229E. Viruses 4(12): 3689-3700, 2012

Infectivity of human coronavirus strain 229E. Journal of Clinical Microbiology 12(3): 462-468, 1980

The genome of human coronavirus strain 229E. Journal of General Virology 39(3): 497-504, 1978

Morphogenesis of avian infectious bronchitis virus and a related human virus (strain 229E). Journal of Virology 1(5): 1019-1027, 1967

Oligonucleotide fingerprints of antigenically related bovine coronavirus and human coronavirus OC43. Archives of Virology 86(1-2): 101-108, 1985

Molecular characterization of the 229E strain of human coronavirus. Advances in Experimental Medicine and Biology 276: 73-80, 1990

Molecular analysis of the human coronavirus (strain 229E) genome. Archives of Virology. Supplementum 7: 63-74, 1993

Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity. Journal of Virology 69(7): 4331-4338, 1995

Isolation and morphology of the internal component of human coronavirus, strain 229E. Intervirology 6(4-5): 197-206, 1975