Radiometric method for pyrazinamide susceptibility testing of Mycobacterium tuberculosis in egg-yolk-enriched BACTEC 12A medium

Woodley, C.L.; Smithwick, R.W.

Antimicrobial Agents and ChemoTherapy 32(1): 125-127


ISSN/ISBN: 0066-4804
PMID: 3126704
DOI: 10.1128/aac.32.1.125
Accession: 041165992

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A radiometric method for testing the susceptibility of Mycobacterium tuberculosis to pyrazinamide in egg-yolk-enriched 12A medium (pH 5.5) is described. We obtained 100% agreement between the 7H10 agar method with 25 microgram of pyrazinamide per ml and the modified radiometric method with a drug concentration of 50 microgram/ml in tests of 90 clinical isolates.