+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Reaction of sodium amoxicillin with Cu(II) ion in a methanolic medium



Reaction of sodium amoxicillin with Cu(II) ion in a methanolic medium



Journal of Pharmaceutical Sciences 80(9): 904-907



The present article considers several physicochemical aspects of the complexation reaction of sodium amoxicillin and Cu(II) ion in a methanolic medium. Analysis of spectrophotometric data demonstrated the formation of two complex species with amoxicillin:Cu(II) ion mole ratios of 1:1 and 2:1. Stability constants (beta) and molar absorptivities at 610 nm (epsilon) of the complexes (20 degrees C) in methanol were calculated simultaneously by a computer program on the basis of absorbance data obtained at 610 nm. The values thus calculated for the 1:1 complex were as follows: log beta 1 = 5.48 +/- 0.21 L.mol-1, epsilon 1 = 70 +/- 2 L.mol-1.cm-1. The values for the 2:1 complex were as follows: log beta 2 = 8.98 +/- 0.17 L2.mol-2 and epsilon 2 = 138 +/- 4 L.mol-1.cm-1. The amoxicillin:Cu(II) ion complexes were quite stable over time.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041179418

Download citation: RISBibTeXText

PMID: 1800718

DOI: 10.1002/jps.2600800921


Related references

Complexation of sodium ampicillin and copper(II) ion in a methanolic medium. Polyhedron 11(9): 1049-1052, 1992

Study of the reaction of complexation of penicillin V with cobalt(II) in methanolic medium. Talanta 39(6): 637-641, 1992

Blood amoxicillin concentrations in agricultural animals and poultry treated intramuscularly with drug forms containing amoxicillin sodium and amoxicillin trihydrate. Veterinarno-MeditsinskiNauki20(9):96, 1983

QUESTION 1: What is the risk of a repeat reaction to amoxicillin or a cephalosporin in children with a history of a non-immediate reaction to amoxicillin?. Archives of Disease in Childhood 102(3): 285-288, 2017

Formation of 2 5 bis d threo tri hydroxypropyl pyrazine and its 6 isomer by the oxidative browning reaction of d xylose with ammonium acetate in a methanolic medium. Agricultural & Biological Chemistry: 1189-1190, 1980

Formation of 2,5-bis-(D-threo-trihydroxypropyl)pyrazine and its 6-isomer by the oxidative browning reaction of D-xylose with ammonium acetate in a methanolic medium. Agricultural and Biological Chemistry 44(5): 1189-1190, 1980

Treatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin. American Journal of Gastroenterology 90(9): 1411-1414, 1995

Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro. European Journal of Dermatology 20(1): 68-73, 2010

Investigation on determination and confirmation of dyrene added to plant extracts gas liquid chromatography and thin layer chromatography of dyrene and products of its reaction in methanolic sodium hydroxide. Journal of the Association of Official Analytical Chemists 53(3): 509-513, 1970

Effect of chemical structure of various penicillins on the stability of beta-lactam group in their molecules. VI. Effects of relative humidity and heat on the stability of amoxicillin trihydrate and amoxicillin sodium in the solid phase. Acta Poloniae Pharmaceutica 46(3): 258-265, 1989

Medium effect on the reaction of gibb's reagent with sodium thiosulphate. Journal of Chemical Technology and Biotechnology Chemical Technology 33(6): 281-285, 2007

Dependence of sodium flow out of muscle fibers on sodium concentration in the medium and electric potential difference between the cell and the medium. Biofizika 13(3): 555-557, 1968

Changes of sodium distribution coefficient and exchange rate between the medium and the muscle during changes in the sodium concentration in the medium. Tsitologiya 14(4): 444-451, 1972

Helicobacter pylori eradication with ecabet sodium, omeprazole, amoxicillin, and clarithromycin versus bismuth, omeprazole, amoxicillin, and clarithromycin quadruple therapy: a randomized, open-label, phase IV trial. Helicobacter 17(6): 458-465, 2012

Reaction of rhizobium meliloti strains to various sodium chloride concentrations in a nutrient medium. Izvestiya Timiryazevskoi Sel'skokhozyaistvennoi Akademii (4): 91-95, 1985