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Reaction of sodium amoxicillin with Cu(II) ion in a methanolic medium

Reaction of sodium amoxicillin with Cu(II) ion in a methanolic medium

Journal of Pharmaceutical Sciences 80(9): 904-907

The present article considers several physicochemical aspects of the complexation reaction of sodium amoxicillin and Cu(II) ion in a methanolic medium. Analysis of spectrophotometric data demonstrated the formation of two complex species with amoxicillin:Cu(II) ion mole ratios of 1:1 and 2:1. Stability constants (beta) and molar absorptivities at 610 nm (epsilon) of the complexes (20 degrees C) in methanol were calculated simultaneously by a computer program on the basis of absorbance data obtained at 610 nm. The values thus calculated for the 1:1 complex were as follows: log beta 1 = 5.48 +/- 0.21 L.mol-1, epsilon 1 = 70 +/- 2 L.mol-1.cm-1. The values for the 2:1 complex were as follows: log beta 2 = 8.98 +/- 0.17 L2.mol-2 and epsilon 2 = 138 +/- 4 L.mol-1.cm-1. The amoxicillin:Cu(II) ion complexes were quite stable over time.

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Accession: 041179418

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PMID: 1800718

DOI: 10.1002/jps.2600800921

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