Reactivity of the dopa-dopamine-noradrenaline-adrenaline system in epileptic patients

Karlov, V.A.; Gleiser, M.A.

Neuroscience and Behavioral Physiology 16(1): 49-53

1986


ISSN/ISBN: 0097-0549
PMID: 3090474
DOI: 10.1007/bf01186890
Accession: 041181238

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Abstract
We examined epileptic patients for the daily urine elimination of dopa, dopamine (DA), noradrenaline (NA), and adrenaline (A). The changes in the excretion of these substances after L-dopa intake and the adrenaline and insulin test were also investigated. In addition to the evidence concerning the preserved reactivity of the dopa-DA-NA-A system to the L-dopa intake, data were obtained indicating its stressing and a reduction in the reserve potentials. The use of the adrenaline test revealed the absence of or a negative, response to Da and A in half the patients, which correlated with certain clinical parameters. In one third of the patients the insulin test was not accompanied by an increase in the excretion of A or its precursors. The findings obtained indicate an insufficiency of homeostatic reactions in epileptics, and possibly a deficiency in the repolarizing mechanisms.

Reactivity of the dopa-dopamine-noradrenaline-adrenaline system in epileptic patients