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Regenerating fish optic nerves and a regeneration-like response in injured optic nerves of adult rabbits

Schwartz, M.; Belkin, M.; Harel, A.; Solomon, A.; Lavie, V.; Hadani, M.; Rachailovich, I.; Stein-Izsak, C.

Science 228(4699): 600-603

1985

ISSN/ISBN: 0036-8075
PMID: 3983646
DOI: 10.1126/science.3983646
Accession: 041204414
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Regeneration of fish optic nerve (representing regenerative central nervous system) was accompanied by increased activity of regeneration-triggering factors produced by nonneuronal cells. A graft of regenerating fish optic nerve, or a "wrap-around" implant containing medium conditioned by it, induced a response associated with regeneration in injured optic nerves of adult rabbits (representing a nonregenerative central nervous system). This response was manifested by an increase of general protein synthesis and of selective polypeptides in the retinas and by the ability of the retina to sprout in culture.

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Related References

Lavie, V.; Harel, A.; Doron, A.; Solomon, A.; Lobel, D.; Belkin, M.; Ben-Basat, S.; Sharma, S.; Schwartz, M. 1987: Morphological response of injured adult rabbit optic nerve to implants containing media conditioned by growing optic nerves Brain Research 419(1-2): 166-172
Blaugrund, E.; Lavie, V.; Cohen, I.; Solomon, A.; Schreyer, D.J.; Schwartz, M. 1993: Axonal regeneration is associated with glial migration : comparison between the injured optic nerves of fish and rats Journal of Comparative Neurology (1911) 330(1): 105-112
Blaugrund, E.; Lavie, V.; Cohen, I.; Solomon, A.; Schreyer, D.J.; Schwartz, M. 1993: Axonal regeneration is associated with glial migration: comparison between the injured optic nerves of fish and rats Journal of Comparative Neurology 330(1): 105-112
Schwartz, M.; Belkin, M.; Hadani, M.; Harel, A.; Lavie, V.; Rachailovich, I.; Solomon, A.; Stein Izsack, C. 1986: Signals of external origin can trigger injured adult rabbit optic nerves to express regeneration like responses Gilad, G M , A Gorio And G W Kreutzberg (Ed ) Experimental Brain Research Suppl, 13 Processes Of Recovery From Neural Trauma; International Symposium, Israel, June 1984 Xiv+369p Springer-Verlag: New York, N Y , Usa; Berlin, West Germany Illus 48-60
Eitan, S.; Solomon, A.; Lavie, V.; Yoles, E.; Hirschberg, D.L.; Belkin, M.; Schwartz, M. 1994: Recovery of visual response of injured adult rat optic nerves treated with transglutaminase Science 264(5166): 1764-1768
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Lavie, V.; Sharma, S.; Harel, A.; Lobel, D.; Solomon, A.; Doron, A.; Belkin, M.; Schwartz, M. 1985: Substances originating from growing nerves induce morphological responses characteristic of regeneration in injured optic nerve of adult rabbit Society for Neuroscience Abstracts 11(2): 1252
Kondo, T. 1979: Biochemical changes in glycerophospholipids, particularly plasmalogen, during an early stage of the Wallerian degeneration of rabbit optic nerves. II. Analysis of degenerative optic nerves Nippon Ganka Gakkai Zasshi 83(5): 420-424
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Belkin, M.; Solomon, A.; Ben Bassat, S.; Lavie, V.; Harel, A.; Assia, E.; Rosner, M.; Hadani, M.; Schwartz, M. 1989: Induction of morphological regeneration in transected adult rabbit optic nerves IOVS Investigative Ophthalmology and Visual Science 30(3): 349