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Regulation of I-A expression by murine peritoneal macrophages: differences linked to the Bcg gene

, : Regulation of I-A expression by murine peritoneal macrophages: differences linked to the Bcg gene. Journal of Immunology 138(5): 1372-1376

We previously reported that Mycobacterium bovis (strain BCG) induces continuous I-A expression when injected into BCG-resistant strains of mice. We have extended this observation by showing that Corynebacterium parvum also induces continuous I-A expression by macrophages from BCG-resistant but not BCG-susceptible mice. We have linked continuous expression to BCG resistance by using C.D2Ityr mice, which are congenic with BCG-susceptible BALB/c mice except for genes on a portion of chromosome 1, which contains the gene(s) for BCG resistance. Macrophages from C.D2Ityr mice continuously expressed I-A, whereas macrophages from BALB/c mice transiently expressed I-A. Continuous expression by macrophages from both Bcgr and Bcgs mice could be induced in vitro with rIFN-gamma. However, the continuous expression of I-A by macrophages from Bcgs mice required the continued presence of IFN-gamma, whereas that by Bcgr macrophages did not. The continuous expression of I-A by macrophages from Bcgs mice was also inhibited by hydrocortisone, cyclohexamide, tunicamycin, and monensin, whereas I-A expression by Bcgr macrophages was not affected. The continuous expression of I-A by macrophages from Bcgr mice did not require its continued synthesis. The significance of these findings to the induction of immunity and to antimicrobial resistance are discussed.

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Accession: 041208910

PMID: 3543128

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Iliev, B.; Vasilev, N., 1977: Organization and productivity of machines used in groups. Group working of agricultural machinery facilitates rational planning of mechanized processes, management and control of the common work process, and better organization of competition between these machines. Graphs and formulae are used to study...

Rodríguez, J.J.; Pickel, V.M., 1999: Enhancement of N-methyl-D-aspartate (NMDA) immunoreactivity in residual dendritic spines in the caudate-putamen nucleus after chronic haloperidol administration. Glutamate receptors of the N-methyl-D-aspartate (NMDA) subtype in the caudate-putamen nucleus (CPN) have been implicated in the adverse motor effects produced by chronic administration of the typical antipsychotic drug haloperidol. To determine th...

Sandberg, K.; Ji, H.; Iida, T.; Catt, K.J., 1992: Intercellular communication between follicular angiotensin receptors and Xenopus laevis oocytes: medication by an inositol 1,4,5-trisphosphate-dependent mechanism. In Xenopus laevis oocytes, activation of angiotensin II (AII) receptors on the surrounding follicular cells sends a signal through gap junctions to elevate cytoplasmic calcium concentration ([Ca2+]i) within the oocyte. The two major candidates for...

Xiao, E.; Xia-Zhang, L.; Ferin, M., 1999: Stress and the menstrual cycle: short- and long-term response to a five-day endotoxin challenge during the luteal phase in the rhesus monkey. Previously, we reported that in the rhesus monkey a 5-day inflammatory-like stress during the early-mid follicular phase acutely stimulates the hypothalamic-pituitary-adrenal axis and exerts effects on the hypothalamic-pituitary-gonadal axis, dela...

Gianniny, Gary L., 2012: Microbial, algal, and metazoan dominated highstand carbonate buildups and the link to lowstand evaporite distribution, Pennsylvanian of the Paradox Basin, SE Utah. In addition to water depth and accommodation space variation, water quality appears to have been a major control on dominant faunal components of carbonate buildups in the carbonate/evaporite system of the Pennsylvanian (Desmoinesian) of the Parad...

Khramov, V. A., 1976: Inhibition of bacterial agmatinase by some aliphatic diamines. Amino derivatives (.apprx. 10) which inhibit agmatinase of Proteus vulgaris are found. Hexamethylenediamine had the highest inhibitory effect among diamines; the inhibitor constant was 2.5 mM. The substitution of an amino group for a methyl group...

Van Valen Leigh M., 1986: Speciation and our own species; discussion. Nature (London) 322(6078): 412

Gyovai F., 1984: Synbiological study of the lizard populations of sandy grasslands. In the course of a 2 yr study, data of 634 individuals of the 3 lizard species (Larcerta taurica, L. agilis and L. viridis) living on a sandy grassland were processed. The density of the lizard population was 557 individuals/ha. The migration of t...

Liu Jintao; Zhang Jiabao; Feng Jie, 2008: Green-Ampt model for layered soils with nonuniform initial water content under unsteady infiltration. The Green-Ampt equation is often used to estimate infiltration in hydrologic modeling. Only a few of the currently used simulation models, however, can simulate infiltration into a heterogeneous soil with nonuniform initial soil water content by t...

Weisburger, John H., 1965: Site of action of carcinogens in the alimentary tract. Attention was directed to 2 classes of compounds that induce lesions of the gastrointestinal tract. The lat type preferentially affects the upper gastrointestinal tract chiefly at the level of the esophagus. The other represented by 3-methyl-2-nap...