EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of growth hormone gene expression: synergistic effects of thyroid and glucocorticoid hormones


, : Regulation of growth hormone gene expression: synergistic effects of thyroid and glucocorticoid hormones. Proceedings of the National Academy of Sciences of the United States of America 74(10): 4293-4295

Cultured rat pituitary cells (GC) respond to thyroid and glucocorticoid hormones by increases in growth hormone production and growth hormone mRNA. When these cells are transferred from medium containing normal animal serum (with 1.8 mug of thyroxine per dl) to a medium containing serum from a thyroidectomized calf, "hypothyroid medium" (with no detectable thyroid hormone), growth hormone production decreases markedly. In cells maintained for 5 days in hypothyroid medium, triiodothyronine induces within 50 hr a 17-fold increase in growth hormone production whereas glucocorticoids, during the same time, produce a negligible (3-fold or less) stimulation. In combination, the two hormones promote a 45-fold stimulation. In all instances the changes in growth hormone production are paralleled by changes in the levels of growth hormone mRNA as measured by cell-free translation. The transfer to hypothyroid medium and the hormonal induction do not affect the relative activities of other mRNAs whose products are detectable on polyacrylamide gels. These studies indicate that thyroid hormone can be an activator of the expression of the growth hormone gene. The results also show that triiodothyronine controls the magnitude of the effect of glucocorticoids on growth hormone mRNA, and provide a model for "permissive" triiodothyronine action. The synergistic effect of these two classes of hormone suggests that they increase levels of growth hormone mRNA by different mechanisms.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 041210855

PMID: 270674

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Budrukkar, A.; Tiwana, M.; Jalali, R.; Munshi, A.; Sarin, R., 2011: Patterns of locoregional treatment of breast cancer among radiation oncologists in India: a practice survey. Journal of Cancer Research and Therapeutics 6(4): 530-536

Giancarlo Polizzi; Alessandro Vitale; Dalia Aiello; Vladimiro Guarnaccia; Pedro Crous; Lorenzo Lombard, 2012: First Report of Calonectria ilicicola Causing a New Disease on Laurus Laurus nobilis in Europe. Crown and root rot has been detected on potted Laurus nobilis plants in a nursery located in the Catania province (Italy). Perithecia referable to a Calonectria species were consistently detected on crowns and stems of symptomatic plants. Based on...

Turrell, W. R.; Slesser, G.; Payne, R.; Adams, R. D.; Gillibrand, P. A., 1996: Hydrography of the East Shetland basin in relation to decadal North Sea variability. Three hydrographic sections running east from the coast of Shetland into the central northern North Sea have been surveyed since 1989. These sections cross the East Shetland Atlantic Inflow, which is one of the three northerly oceanic inflows to t...

Anonymous, 2011: Targeting top 911 callers can trim cost, improve patient care. Repeated unnecessary 911 calls are a common drain on the manpower and finances of emergency medical services, but a pilot program that identified Baltimore City's top 911 callers and coupled them with a case worker has succeeded in drasticall...

Bellezza, E.; Mechelli, L.; Arcelli, R., 1993: Corneal pigmentation in the dog. Histopathological and ultrastructural findings. Samples of corneal tissue from 2 blind dogs (a 7-year-old German Shepherd and a 9-year-old mongrel) with complete bilateral corneal pigmentation and a history of chronic superficial keratitis were examined histopathologially and by electron micros...

Comerci G.D., 1976: Teaching and learning in the ambulatory setting. Paediatrician 5(3): 163-171

Bunin, N.; Aplenc, R.; Grupp, S.; Pierson, G.; Monos, D., 2006: Unrelated donor or partially matched related donor peripheral stem cell transplant with CD34+selection and CD3+addback for pediatric patients with leukemias. Unmodified peripheral stem cell transplants are associated with an increased risk of extensive chronic GVHD. T depletion may reduce this risk, but the risk of graft failure or relapse may increase. To decrease the risks of both extensive chronic G...

Holmes T.W.; Mackie T.R., 1991: Progress on an algorithm for the optimization of external beam radiotherapy. Medical Physics (Woodbury) 18(3): 623

Hammond, D.C., 2010: Discussion. Shaping the breast in aesthetic and reconstructive breast surgery: an easy three-step principle. Part III--reconstruction following breast conservative treatment. Plastic and Reconstructive Surgery 124(1): 41-42

Gilbert, H., 1983: Jojoba, 1979-1983 Mainly cultivation. Quick bibliography series National Agricultural Library: 83 (83-30)