+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of hemoglobin synthesis during the development of the red cell (first of three parts)

, : Regulation of hemoglobin synthesis during the development of the red cell (first of three parts). New England Journal of Medicine 297(24): 1318-1328

Mouse erythroleukemia cells were used for experimental work; they resemble proerythroblasts and basophilic erythroblasts morphologically, exhibit several other phenotypic markers of erythroid cells and can be maintained in suspension culture. Determination of the primary sequences of the various globin mRNA's provided the ultimate proof for selective codon use and, therefore, for the selective requirements for various isoaccepting tRNA's in animal cells. The structural basis for many hemoglobinopathies were also defined. The mRNA sequences reveal sites where gene rearrangements might occur and provide the necessary information to make initial predictions regarding secondary structure and interaction of mRNA with the ribosomes. The molecular lesions in thalassemia were intensely studied to provide insight into the mechanisms of gene regulation.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 041210924

PMID: 335250

DOI: 10.1056/NEJM197712152972404

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Williams, R.W.; Clark, S.E.; Meyerowitz, E.M., 1999: Genetic and physical characterization of a region of Arabidopsis chromosome 1 containing the CLAVATA1 gene. With the advance of Arabidopsis as a model system for understanding plant genetics, development and biochemistry, a detailed description of the genome is necessary. As such, focused projects are underway to map and sequence the Arabidopsis nuclear...

Enoksson, M.; Robertson, J.D.; Gogvadze, V.; Bu, P.; Kropotov, A.; Zhivotovsky, B.; Orrenius, S., 2004: Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. Caspases are cysteine proteases that play a central role in the execution of apoptosis. Recent evidence indicates that caspase-2 is activated early in response to genotoxic stress and can function as an upstream modulator of the mitochondrial apop...

Payer, L.J., 1974: American medical students abroad: group finds way in French system. Science 185(4151): 594-596

Webster, R.; Butler, B. E., 1976: Soil classification and survey studies at ginninderra australia. Studies were made of the interrelations of soil properties, their spatial variation and the relations between sampling sites at Ginninderra Experiment Station near Canberra [Australia]. Soil morphology was recorded at 0-10 cm, 15-25 cm (usually A2...

Koehler H.; Schafmayer A.; Peiper H J., 1987: Follow up results of surgical treatment in chronic pancreatitis. Between 1968 and 1981, 138 patients (101 male and 37 female) with a mean age of 38 years were operated on for chronic pancreatitis at the Department of General Surgery, University of Gottingen [West Germany]. Pathogenetic factors were alcohol abus...

Joksović, D.; Kusić, R.; Randelović, S.; Jandrić, D., 1987: Clinical observations in acute benzodiazepine poisoning. Medicinski Pregled 40(1-2): 61-63

Chavand, Aurelie; Grandjean, Helene; Vignes, Michel, 2007: Ladolescent face au cancer et sa place dans la famille. Adolescent medicine is expanding in Europe with particular attention being given to cancer of adolescents and its treatment, At a time where specialised units for adolescents are being born, it is essential to collect the current knowledge on the...

Ahlstrom, C.; Kircher, K., 2016: Changes in glance behaviour when using a visual eco-driving system - A field study. While in-vehicle eco-driving support systems have the potential to reduce greenhouse gas emissions and save fuel, they may also distract drivers, especially if the system makes use of a visual interface. The objective of this study is to investiga...

Latifov, Nl; Grislis, Svo, 1981: Resources of warmth and moisture for the pasture stand in the Moscow Region Air temperature and precipitations.1. Izvestiia Timiriazevskaia sel'skokhoziaistvennaia akademiia: ) 38-42

White, C.T.; Hansen, D., 1975: Complex binocular interaction and other effects in the visual evoked response. One article dealing with some of the research on binocular interaction effects being carried out in our laboratory has appeared previously in this Journal (White and Bonelli). In that study, it was found that the amplitude of the visually evoked c...