EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of hepatic gluconeogenesis and glycogenolysis by phosphorylated glycerol and glycolytic intermediates in diabetic and control Chinese hamsters


, : Regulation of hepatic gluconeogenesis and glycogenolysis by phosphorylated glycerol and glycolytic intermediates in diabetic and control Chinese hamsters. Biochemical Medicine and Metabolic Biology 37(2): 228-234

Metabolic regulation of gluconeogenesis and glycogenolysis by two phosphorylated derivatives of glycerol, G3P, and DHAP, and by F2,6BP, was assessed in vitro in liver homogenates obtained from Chinese hamsters (C. griseus) of two types: diabetic animals from sublines with consistent glycosuria and hyperglycemia, and normoglycemic controls. Only FBPase was sensitive to inhibition by the phosphorylated metabolites. G3P was weakly inhibitory of FBPase. Addition of 7 X 10(-3) M DHAP halved FBPase activity in the diabetic hamsters and 4 X 10(-3) M DHAP produced the same effect in the controls. The other gluconeogenic enzymes and phosphorylase a were only negligibly inhibited. In contrast, F2,6BP inhibited FBPase at concentrations in the micromolar range. Liver homogenates from diabetic hamsters appeared significantly more sensitive to F2,6BP inhibition of FBPase than those from controls at concentrations 0.6 X 10(-6) M and higher. These data indicate that in well-fed hamsters phosphorylated glycerol derivatives are unlikely to regulate hepatic gluconeogenesis at physiologic concentrations. However, the effects of F2,6BP on gluconeogenesis and glycolysis may be linked to those mediated by insulin. Thus, the deficiency of insulin, elevated end-organ insulin resistance, the alteration in the glucagon-insulin interaction, or a combination of these possible causes can be involved in an abnormal regulation of glycolysis and gluconeogenesis at the FBPase step, associated with changes in F2,6BP concentration.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 041210949

PMID: 2954569

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Lundeheim, N.; Rydhmer, L., 1990: Genetic analysis of osteochondrosis and leg weakness in the Swedish Landrace pig population. Records of 6294 pigs progeny tested in Sweden between 1985 and 1989 were analysed by Restricted Max. Likelihood procedures for growth and carcass and scores for osteochondrosis and leg weakness. The hsuperscript 2s for osteochondrosis and leg weak...

Stranger, J. H.; Millard, R.; Asprey, G. F., 1960: Automation in the greenhouse. A new approach. Gloxinia plants were grown in a box, 8 ft. x 2 ft. 6 in. x 2 ft. 3 in. deep, with an electric soil heater in the lower half and a 20-ft. length of perforated plastic hose surrounded by a plastic sleeve 6 in. below the surface of the rooting medium...

Lockwood, D.H.; Turkington, R.W.; Topper, Y.J., 1966: Hormone-dependent development of milk protein synthesis in mammary gland in vitro. Insulin, hydrocortisone and prolactin acting synergistically selectively stimulate in vitro the synthesis of milk proteins by the pregnant mouse mammary gland. Synthesis of soluble cytoplasmic non-milk protein derived from epithelial cells is stim...

Borchgrevink P.C.; Holten T.; Jynge P., 1987: Tissue electrolyte changes induced by high doses of diuretics and rats. High doses of furosemide administered orally to growing rats for 4 weeks induced a pronounced fall in the concentration of magnesium and potassium in plasma, of magnesium in bone and potassium in skeletal muscle, but did not cause any reduction of...

Fishel S.B.; Edwards R.G.; Purdy J.M.; Steptoe P.C.; Webster J.; Walters E.; Cohen J.; Fehilly C.; Hewitt J.; Rowland G., 1985: Implantation abortion and birth after in vitro fertilization using the natural menstrual cycle or follicular stimulation with clomiphene citrate and human menopausal gonadotropin. The incidence of pregnancy and abortion was analyzed in 1679 patients having embryos replaced after oocyte recovery and in vitro fertilization in order to alleviate their infertility. In these patients, 364 pregnancies were achieved and 108 aborti...

Agostino, D.; Agostino, N., 1979: Role of operative trauma: explosive metastases of similar size following amputation of the primary leg tumor. Trauma produced by amputation of a limb bearing the primary tumor influenced pulmonary metastases of the Carcinosarcoma of Walker 256 of the rat. This enhancement was present in 38% of the animals following the removal of a limb bearing the primar...

Shatilina L.V.; Ballyuzek M.F.; Gurevich V.S., 1988: Some patterns of lipid peroxidation in the thrombocytes of patients with ischemic heart disease. Interaction between lipid peroxidation activation and the antioxidant system was studied in thrombocytes of patients with cardiovascular pathology. Positive correlation between superoxide dismutase activity and malonic dialdehyde content was found...

Fulbright, Dw; Ravenscroft, Av, 1987: Recovering American chestnut trees in Michigan: more widespread than first thought. Annual report of the Northern Nut Growers Association: 8th) 195-197

Nishimura, Takeshi; Okuda, Hitoshi, 1993: Arterial supply of the maxillary teeth in the crab-eating monkey. Summary: Superior dental rami diverging from arterial multi-resources of the crab-eating monkey were investigated by means of plastic corrosion castings. Correlations between the dental ramus/rami entering the apical foramen/foramina of each maxil...

Hardwick, James P.; Gonzalez, Frank J.; Kasper, Charles B., 1983: Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16a-carbonitrile: characterization of its mRNA, gene, and induction response. The Journal of Biological Chemistry 258: 182-6