+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of herpes simplex virus-specific lymphoproliferation by suppressor cells

, : Regulation of herpes simplex virus-specific lymphoproliferation by suppressor cells. Journal of Virology 56(1): 1-6

We investigated the regulation of the herpes simplex virus (HSV)-specific lymphoproliferative response (LPR) by suppressor cells. The chief cell types in HSV-immune splenocytes proliferating in response to the antigen were Lyt 1+ and Lyt 2+ T cells, which accounted for approximately 60 and 40% of the response, respectively. Because the total responsiveness of splenocytes was enhanced after depletion of Lyt 2+ cells, the LPR was assumed to be subject to regulation by an Lyt 2+ suppressor cell. This was shown to be the case with an experimental design in which suppressor cell activity was induced in one culture, the cells were irradiated, and the effects on LPR were measured in a test antigen-stimulated culture. The cell responsible for suppression was shown to be Lyt 2+ IJ+, and the actual suppressor effect was not antigen specific. Cellular requirements for the generation of suppression were also investigated. The three distinct cell types that appeared to be required were Lyt 2+ and Lyt 1+ T cells and an IJ+ antigen-presenting cell. Of the three cell types, only the Lyt 2+ cell needed to be from HSV-immune animals. The implications of our model system for the better understanding of the role of immunity in herpesvirus pathogenesis are discussed.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 041210990

PMID: 2993641

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Relini, Guilio .; Massaro, Elisabetta .; Simoni, Rossana ., 2001: Papers of the XXXI Congress of the Italian Society of Marine Biology Sharm El Sheikh 13-20 May 2000 Atti XXXI Congresso SIBM Sharm El Sheikh 13-20 Maggio 2000. Biologia Marina Mediterranea, 81: i-vi, 1-440

Manning F.S., 1982: A survey of pollutant emission levels in waste waters and residuals from the petroleum refining industry. Environment International: 237-258

Hernández Fernández, C., 2000: Stents in the urinary system. Revista Clinica Espanola 200(5): 242-244

Cormand, B.; Vilageliu, L.; Balcells, S.; Gonzàlez-Duarte, R.; Chabás, A.; Grinberg, D., 1996: Two novel (1098insA and Y313H) and one rare (R359Q) mutations detected in exon 8 of the beta-glucocerebrosidase gene in Gaucher's disease patients. Human Mutation 7(3): 272-274

McColloch, J. W., 1922: The Eleodes of Riley County, Kansas. Transactions of the Kansas Academy of Science, 30: 182-183

Thanseem, I.; Joseph, A.; Thulaseedharan, A., 2005: Induction and differential expression of beta-1,3-glucanase mRNAs in tolerant and susceptible Hevea clones in response to infection by Phytophthora meadii. Most cultivated rubber tree (Hevea brasiliensis Willd. ex A. Juss.) clones in India are susceptible to abnormal leaf fall disease (ALF), which is caused by various Phytophthora species and results in yield losses of up to 40%. Because the conventi...

Hu, Z.; Gu, J.; Cao, L.; Jin, D., 2008: The CT study of relation between the height of middle concha and paranasal sinusitis. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 21(20): 919-921

Farb, J.B.; Lee, E.Y., 2006: Clinical image. Infiltrative renal lymphangioma in a pediatric patient. Pediatric Radiology 36(7): 718-718

Fernald, M. L., 1940: The problem of conserving rare native plants. Ann Rept Smithsonian Inst 1939: 375-391

KATAN, M., 1964: Fetishism, Splitting Of The Ego, And Denial. International Journal of Psycho-Analysis 45(): 237-245