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Regulation of human natural killing by lysosomotropic and thiol-reactive agents


, : Regulation of human natural killing by lysosomotropic and thiol-reactive agents. Immunology 55(4): 647-654

Treatment of human peripheral blood lymphocytes (PBL) with ammonium or other lysosomotropic amines eliminates natural killing (NK) activity of effector cells without affecting their viability. Inhibition of NK by these reagents is probably due to blocking of events subsequent to effector cell target cell binding but before programming for cytolysis. Treatment of K562 target cells with the same reagents has no effect on target cell sensitivity to NK. Pretreatment of effector cells with the NK inhibitory lysosomotropic agents decreases lysosomal thiol cathepsin activity without affecting the lysosomal acid phosphatase activity. Thiol-reactive agents, tosyl-L-lysine chloromethyl ketone (TLCK) and iodoacetamide also inhibit NK and thiol cathepsin activity in PBL. These data suggest a role for thiol-containing enzymes in the early stages of NK cytolysis.

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Accession: 041211128

PMID: 4018845

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Poljakov, P. E., 1966: The relation between the body weight of Schwyz bulls, the volume of their testes and semen production. In 1963 at the Smolensk A.I. Station, 2 groups of 11 and 9 resp. had an av. body weight of 815 and 933 kg. and an av. age of 52 and 54 mths.

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The American Phytopathological Society Committee On Standardization Of Fungicidal Tests, 1947: Test tube dilution technique for use with the slide-germination method of evaluating protectant fungicides. In a rapid and simple technique, details are given for diluting readily suspensible chemicals in geometric series in test tubes using a minimum of tubes, pipettes, graduates, and flasks. Spores are added to the various dilutions and aliquots pipet...

Momeni, M.H., 1979: Competitive radiation-induced carcinogenesis: an analysis of data from beagle dogs exposed to 226Ra and 90Sr. Health Physics 36(3): 295-310

Anonymous, 1956: 'Spindle stand' of Pines. Pot experiments have been completed on the possible causes of 'spindle stand' in Pinus radiata growing in Young sand from Mount Burr. The unthrifty appearance could not be improved by providing more water, more mycorrhiza, or more needle...

KING, E.S.J., 1949: The intedigital pilonidal sinus. Australian and New Zealand Journal of Surgery 19(1): 29-33

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Joh, Toshio; Malick, Dia Habib; Yazaki, Junshi; Hayakawa, Toshiro, 1996: Purification and characterization of secreted acid phosphatase under phosphate-deficient condition in Pholiota nameko. Activity of acid phosphatase secreted by mycelia of Pholiota nameko on cultivation for 30d in Pi-depleted medium was 88-fold higher than the corresponding activity in the Pi-supplied medium. One isozyme of the secreted acid phosphatases was purifi...

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