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Regulation of in-vivo differentiation of myeloid leukemic cells by antigen-specific helper T lymphocytes


, : Regulation of in-vivo differentiation of myeloid leukemic cells by antigen-specific helper T lymphocytes. Leukemia Research 10(10): 1165-1168

There are clones of myeloid leukemic cells that can be induced to differentiate in vitro and in vivo by normal macrophage and granulocyte differentiation-inducing protein MGI-2 (= DF). The differentiation of these myeloid leukemic cells in vivo is regulated by a cell mediated immune response which requires T lymphocytes. We now show that differentiation of myeloid cells in vivo can be induced by antigen-specific helper T lymphocytes and that this is associated with the ability of the helper T cells to produce myeloid cell differentiation-inducing protein MGI-2. Antigen specific helper T cells can accumulate at a site that contains the antigen. It is suggested that migration in response to antigen of helper T cells producing differentiation factors may play an important role in inducing in vivo differentiation of leukemic cells.

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Accession: 041211224

PMID: 2430146

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Related references

Lotem, J.; Ben-Nun, A.; Sachs, L., 1986: Regulation of in vivo differentiation of myeloid leukemic cells by antigen specific helper t lymphocytes. There are clones of myeloid leukemic cells that can be induced to differentiate in vitro and in vivo by normal macrophage and granulocyte differentiation-inducing protein MGI-2 (=DF). The differentiation of these myeloid leukemic cells in vivo is...

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