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Regulation of interferon gene expression: mechanism of action of the If-1 locus

, : Regulation of interferon gene expression: mechanism of action of the If-1 locus. Journal of Virology 62(4): 1125-1131

We have examined the mechanism of action of the If-1 interferon (IFN) regulatory locus. This locus controls the level of circulating IFN produced in inbred mice in response to intravenous injection of Newcastle disease virus. Mice carrying the If-1h (high) allele show circulating IFN levels 10- to 15-fold higher than those carrying the If-1l (low) allele. In this report we show that induced splenocytes from If-1h and If-1l mice produce IFN at levels which are in the same proportions as those found in the circulation. Higher levels of IFN-specific mRNA were observed in splenocyte populations from If-1h animals. This was due to increased transcription of IFN genes. At the same time, the high- and low-producing populations showed no significant difference in the number of IFN mRNA-containing cells. We conclude that the effect of If-1 in the spleen is to control the levels of transcription of the IFN genes in individual induced splenocytes.

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Accession: 041211311

PMID: 3346943

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Lycheva T.A.; Marakusha B.I., 1978: The effect of transmission of different types of mutations in the stra locus on the virulence of shigella flexneri. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii (5): 26-31

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Neelam Misra; Gupta, A. K., 2005: Effect of salt stress on proline metabolism in two high yielding genotypes of green gram. The effect of salt stress was studied on free proline accumulation, activities of pyrroline-5-carboxylate reductase (P-5-CR), proline oxidase and gamma -glutamyl kinase, glycinebetaine levels and chlorophyll contents in two cultivars of green gra...

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