+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relatedness of rabbit coronavirus to other coronaviruses



Relatedness of rabbit coronavirus to other coronaviruses



Advances in Experimental Medicine and Biology 218: 521-527



Rabbit coronavirus (RbCV) was apparently first encountered in 1961 when Scandinavian investigators observed occasional mortality in rabbits used to propagate the Nichols strain of Treponema pallidum. Mortality rates reached 50 percent by 1968 and 75 percent by 1970. Contaminated samples of T. pallidum were brought to the Johns Hopkins University School of Medicine, a World Health Organization center for the study of treponematoses. There it was established that the causative agent was filterable, the heart was the target organ, and the agent was determined by electron microscopy to be a coronavirus. Also, complement fixing antibodies to the human coronaviruses 229E (two way cross) and 0C43 (one way cross) were demonstrated in surviving rabbits. Immunofluorescent staining with anti-229E serum localized fluorescence in the interstitial tissue of the myocardium. Antiserum to RbCV cross reacted with coronaviruses of three other diseases, feline infectious peritonitis (FIPV), canine coronavirus diarrhea (CCV), and transmissible gastroenteritis (TGEV) by radioimmunoassay. In plaque neutralization tests, a slight reduction was observed against TGE and CCV but not against FIP. Antiserum to 229EV, CCV, FIPV and to a lesser degree TGEV partially blocked the clinical course of the disease and reduced mortality. Slight protection was afforded rabbits by vaccination with, in descending order of survivors, CCV, FIPV, and TGEV. Vaccination with calf diarrhea coronavirus (CDCV) provided no protection.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041217116

Download citation: RISBibTeXText

PMID: 2829566


Related references

Coronaviruses and gastroenteritis: evidence of antigenic relatedness between human enteric coronavirus strains and human coronavirus OC43. Microbiologica 7(4): 315-322, 1984

Human enteric coronaviruses: antigenic relatedness to human coronavirus OC43 and possible etiologic role in viral gastroenteritis. Journal of Infectious Diseases 151(5): 796-803, 1985

Antigenic and genomic relatedness of turkey-origin coronaviruses, bovine coronaviruses, and infectious bronchitis virus of chickens. Avian diseases 45(4): 978-984, 2001

Coronavirus isolates SK and SD from multiple sclerosis patients are serologically related to murine coronaviruses A59 and JHM and human coronavirus OC43, but not to human coronavirus 229E. Journal of Virology 38(1): 231-238, 1981

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. Journal of Infectious Diseases 209(7): 995, 2014

Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development. Human Vaccines and Immunotherapeutics 13(1): 186-189, 2017

Coronaviruses SD and SK share extensive nucleotide homology with murine coronavirus MHV-A59, more than that shared between human and murine coronaviruses. Virology 126(2): 669-677, 1983

Evolutionary history of the closely related group 2 coronaviruses: porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43. Journal of Virology 80(14): 7270-7274, 2006

Comparative molecular epidemiology of two closely related coronaviruses, bovine coronavirus (BCoV) and human coronavirus OC43 (HCoV-OC43), reveals a different evolutionary pattern. Infection Genetics and Evolution 40: 186-191, 2016

Antigenic relatedness of human enteric coronavirus strains to human coronavirus OC43: a preliminary report. Journal of Infectious Diseases 150(4): 618-619, 1984

Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers. Current Opinion in Infectious Diseases 27(5): 411-417, 2014

Evidence of close relatedness between turkey and bovine coronaviruses. Advances in Experimental Medicine and Biology 276: 457-460, 1990

Relatedness of virion and intracellular proteins of the murine coronaviruses JHM and A59. Advances in Experimental Medicine and Biology 142: 103-110, 1981

More and More Coronaviruses: Human Coronavirus HKU1. Viruses 1(1): 57-71, 2009

Genome comparison between SARS-associated coronavirus and other Coronaviruses. Virologica Sinica 18(4): 335-339, 2003