+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relation between adrenergic neurogenic contraction and alpha 1-adrenoceptor subtypes in dog mesenteric and carotid arteries and rabbit carotid arteries



Relation between adrenergic neurogenic contraction and alpha 1-adrenoceptor subtypes in dog mesenteric and carotid arteries and rabbit carotid arteries



British Journal of Pharmacology 102(1): 210-214



1. We examined the distribution of alpha 1-adrenoceptor subtypes and their relation to adrenergic neurogenic contraction induced by electrical transmural stimulation in the dog mesenteric and carotid arteries and the rabbit carotid artery. 2. In the dog mesenteric artery, contraction to noradrenaline was competitively inhibited by HV723 (pKB = 9.37) and prazosin (pKB = 8.40). Pretreatment with chlorethylclonidine (CEC) slightly attenuated only the contractions induced by low concentrations of noradrenaline. Contraction induced by electrical transmural stimulation was inhibited at lower concentrations of HV723 than of prazosin. 3. In the dog carotid artery, contraction to noradrenaline was inhibited with higher affinity by prazosin (pKB = 9.82) than by HV723 (pKB = 8.47). Prazosin was also more potent than HV723 in inhibiting the contraction to electrical stimulation. Pretreatment with CEC markedly attenuated or abolished contraction to noradrenaline and electrical stimulation. 4. In the rabbit carotid artery, prazosin inhibited noradrenaline-induced contraction biphasically (pKB = 9.91 and 8.60). After CEC pretreatment, contraction to noradrenaline was attenuated moderately and the high affinity site for prazosin was abolished. HV723 competitively inhibited the noradrenaline response with a similar pKB value (approximately 8.5) regardless of CEC treatment. Contraction to electrical stimulation was inhibited by prazosin more effectively than by HV723 in preparations not treated with CEC, while it was equipotently inhibited by both antagonists in CEC-treated preparations. 5. These results suggest that the contractions induced by endogenous and exogenous noradrenaline are mediated through the same subtypes of alpha,-adrenoceptor distributed in each artery; according to our recent subclassification: alpha 1N subtype in the dog mesenteric artery, alpha 1H subtype in the dog carotid artery and alpha lH and alpha 1L subtypes in the rabbit carotid artery. Different susceptibility to alpha l-adrenoceptor antagonists of sympathetic adrenergic responses in various blood vessels may be related to heterogeneous involvement of distinct alpha,-adrenoceptor subtypes in the sympathetic response.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041217249

Download citation: RISBibTeXText

PMID: 1675144


Related references

Pharmacological characterization of alpha-adrenergic receptor subtypes mediating contraction in human mesenteric arteries and veins. Blood Vessels 22(4): 179-195, 1985

Insights into the functional roles of alpha(1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice. British Journal of Pharmacology 144(4): 558-565, 2005

Effects of hypercholesterolemia on alpha-1 adrenoceptor mediated vasoconstriction in rabbit common carotid arteries. Japanese Circulation Journal 57(7): 683, 1993

Vascular responsiveness of rabbit common carotid, renal and femoral arteries to alpha-adrenoceptor agonists. Japanese Journal of Pharmacology 61(3): 171-176, 1993

Vascular alpha-1 antagonistic and agonistic effects of beta adrenoceptor agonists in rabbit common carotid arteries. Journal of Pharmacology and Experimental Therapeutics 263(2): 457-461, 1992

Vascular alpha-1 antagonistic and agonistic effects of beta-adrenoceptor agonists in rabbit common carotid arteries. Japanese Journal of Pharmacology 61(SUPPL 1): 223P, 1993

Alterations of vascular alpha 1-adrenergic contractile responses in hypercholesterolemic rabbit common carotid arteries. Journal of Cardiovascular Pharmacology 22(1): 58-64, 1993

Existence of Functional 1A- and 1D- but No 1B-Adrenoceptor Subtypes in Rat Common Carotid Arteries. The Japanese Journal of Pharmacology 88(2): 146-150, 2002

Alpha adrenoceptor subtypes in canine mesenteric arteries and veins. Federation Proceedings: Abstract 400, 1984

Existence of functional alpha1A- and alpha1D- but no alpha1B-adrenoceptor subtypes in rat common carotid arteries. Japanese Journal of Pharmacology 88(2): 146-150, 2002

Nitric oxide and alpha-adrenergic reactivity of developing cerebral arteries Role of alpha-1- and alpha-2-adrenoceptor subtypes. Pediatric Research 41(4 PART 2): 59A, 1997

Alpha-1-Adrenoceptor subtypes mediating contraction of arteries in spontaneously hypertensive rats. Japanese Journal of Pharmacology 61(SUPPL 1): 223P, 1993

Investigation of alpha-1-adrenoceptor subtypes in rabbit cutaneous arteries. British Journal of Pharmacology 119(PROC SUPPL ): 92P, 1996

Handling of cytoplasmic Ca2+ by the sarcoplasmic reticulum during alpha 1-adrenoceptor-mediated contraction of rat mesenteric resistance arteries. Japanese Journal of Pharmacology 64(2): 89-96, 1994

Immunohistochemical detection of alpha-2-adrenoceptor subtypes using alpha-2 subtype-specific antibodies in rabbit interlobular arteries. FASEB Journal 10(3): A71, 1996