+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relationships between clinical effects and monoamine metabolites and amino acids in sulpiride-treated schizophrenic patients



Relationships between clinical effects and monoamine metabolites and amino acids in sulpiride-treated schizophrenic patients



Psychopharmacology 101(3): 324-331



Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (400, 800 or 1200 mg) according to a double dummy blind randomized administration schedule. The psychopathology of the patients was rated by the Comprehensive Psychopathological Rating Scale (CPRS) and the Nurse's Observation Scale for Inpatient Evaluation (NOSIE). The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA), 4-hydroxy-3-methoxy-phenylglycol (HMPG) and the amino acids tyrosine, tryptophan, glutamate and glutamine were measured in serum before and once a week during sulpiride treatment. There were no significant correlations between the CPRS or the NOSIE morbidity scores and the biochemical measures before drug treatment. HVA levels were not correlated to rating scores during treatment, but after 6 weeks HVA had decreased significantly in the patients with a good response but not in the patients with a poor response. A negative relationship between 5-HIAA levels and depressive and negative symptoms was found. Non-responders according to the subscale for depression had low 5-HIAA levels throughout the treatment. An increase of tryptophan was correlated to improvement in the early part of treatment. High levels of glutamate or glutamine were found in non-responders before treatment. During treatment an increase of the glutamate level was correlated to improvement. Low levels of glutamine were related to improvement according to global and NOSIE (total) rating scores. Peripheral biochemical measures may be a valuable tool in the study of pathophysiological mechanisms and treatment effects in patients with schizophrenia.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041224837

Download citation: RISBibTeXText

PMID: 2362952

DOI: 10.1007/bf02244049


Related references

Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment. Psychopharmacology 99(3): 322-327, 1989

Relationships between drug concentrations in serum and CSF, clinical effects and monoaminergic variables in schizophrenic patients treated with sulpiride or chlorpromazine. Acta Psychiatrica Scandinavica. Supplementum 311: 49-74, 1984

Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls. British Journal of Psychiatry 147: 276-282, 1985

Time course for effects of sulpiride and chlorpromazine on monoamine metabolite and prolactin levels in cerebrospinal fluid from schizophrenic patients. Acta Psychiatrica Scandinavica. Supplementum 311: 75-92, 1984

Plasma amino acids in schizophrenic patients with methionine or cysteine loading and a monoamine oxidase inhibitor. American Journal of Clinical Nutrition 24(9): 1053-1059, 1971

Study of the clinical effects of sulpiride and perphenazine in 82 schizophrenic patients by the double blind method. L'Encephale 2(1): 73-83, 1976

Effects of midazolam and buspirone on in vivo concentration of amino acids and monoamine metabolites in the rat hippocampus. Pharmacological Reports 60(2): 209-218, 2008

Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid. European Journal Of Pharmacology. 230(3): 321-326, 1993

The selective effects of alpha-methyl aromatic amino acids on brain monoamine metabolites and behavior in cats. Research Communications in Chemical Pathology and Pharmacology 12(2): 255-265, 1975

Relationship between drug concentrations in serum or cerebro spinal fluid and clinical effects in schizophrenic patients with sulpiride or chlorpromazine. Acta Pharmacologica et Toxicologica Suppl. 53(1): 79, 1983

CSF monoamine metabolites in schizophrenic patients. Acta Psychiatrica Scandinavica 66(5): 350-360, 1982

Study of visually evoked potentials in schizophrenic patients treated with sulpiride. Arzneimittel-Forschung 30(8): 1306-1309, 1980

Saccadic eye movement abnormalities in schizophrenic patients treated with clozapine, risperidone or sulpiride. Schizophrenia Research 18(2-3): 222, 1996

CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide. Psychological Medicine 15(2): 335-340, 1985

Relationships among biochemical, clinical, and pharmacokinetic variables in neuroleptic-treated schizophrenic patients. Advances in Biochemical Psychopharmacology 24: 521-528, 1980