+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Reproducibility of emesis by orally administrated copper sulfate in cats

Reproducibility of emesis by orally administrated copper sulfate in cats

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 72(3): 287-291

Adult cats were administered oral threshold doses of copper sulfate every week. As the cats vomited in 70 out out 80 cases, the reproducibility was 88%. Peripheral vomiting threshold dose was 40 mg/head or less, while the threshold dose for oral copper sulfate emesis after T4 transection and vagotomy was more than 160 mg/head. The following method is thus proposed for application in evaluating an antimetic for oral copper sulfate. Adult cats are to be given the emetic once a week. The threshold dose should be determined in three dose levels; 10, 20, 40 mg/head. The cats with a threshold of more than 40 mg or latency of less than 5 min or of more than 45 min are to be excluded. Inhibition of emesis or a considerable prolongation of latency is the sign of an antimetic action. A positive action of an antiemetic must be followed by another test with the threshold dose of copper sulfate alone. If the cat does not respond to the threshold dose after 2 administrations, the case must be excluded. It is considered positive when 3 cases are inhibited among 4 or more than 50% among more than 5.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 041242133

Download citation: RISBibTeXText

PMID: 986987

Related references

Effectiveness of several antiemetics in vomiting induced by orally administrated copper sulfate in cats and dogs. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 72(3): 293-296, 1976

Reproducibility of copper sulfate emesis by oral threshold dose in cats. Folia Pharmacologica Japonica 72(3): 287-291, 1976

Reproducibility of copper sulfate emesis by oral administration in dogs. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 71(2): 169-173, 1975

Effectiveness of some anti emetics on oral copper sulfate emesis in cats and dogs. Folia Pharmacologica Japonica 72(3): 293-296, 1976

Anti-inflammatory, counteractive, and preventive effects of orally administrated oat extracts on dextran sulfate sodium-induced colitis in mice. Food Science and Biotechnology 24(2): 619-628, 2015

Maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine reduces the incidence of emesis in cats. Journal of Feline Medicine and Surgery 19(8): 876-879, 2017

Reproducibility of sulfate conjugation of orally administered amines in man. Biogenic Amines 6(1): 81-86, 1989

Effect of ondansetron a 5 ht 3 antagonist on copper sulfate induced emesis in the ferret. Biogenic Amines 8(2): 79-86, 1991

Effects of sn 307 gr 38032f on emesis induced by antineoplastic agents and copper sulfate in ferrets. Japanese Journal of Pharmacology 55(Suppl. 1): 152P, 1991

Involvement of 5-HT3 receptors and vagal afferents in copper sulfate- and cisplatin-induced emesis in monkeys. European Journal Of Pharmacology. 249(1): 13-18, 1993

Emetic effects of copper sulfate and cisplatin in monkeys and blockade of the emesis by abdominal vagotomy. Japanese Journal of Pharmacology 61(Suppl. 1): 197P, 1993

Efficacy of an ondansetron orally disintegrating tablet: a novel oral formulation of this 5-HT(3) receptor antagonist in the treatment of fractionated radiotherapy-induced nausea and emesis. Emesis Study Group for the Ondansetron Orally Disintegrating Tablet in Radiotherapy Treatment. Clinical Oncology ) 11(5): 340-347, 1999

Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews. American Journal of Physiology. Regulatory Integrative and Comparative Physiology 306(5): R341-R351, 2014

Blood levels after orally administrated novobiocin. Giorn Mal Infett E Parassit 9(11): 1964-1965, 1957

Transfer of orally administrated iodine-131 into chicken eggs. Applied Radiation and Isotopes 58(3): 299-307, 2003