+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Respective roles of short- and long-range interactions in protein folding



Respective roles of short- and long-range interactions in protein folding



Proceedings of the National Academy of Sciences of the United States of America 75(2): 559-563



A lattice model of protein is studied by a Monte Carlo simulation method. The native conformation of the lattice protein molecule is stabilized by specific long-range and short-ranged interactions. By comparing results of simulation for different relative weights of the long- and short-range interactions, it is concluded that the specific long-range interactions are essential for highly cooperative stabilization of the native conformation and that the short-range interactions accelerate the folding and unfolding transitions.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041249146

Download citation: RISBibTeXText

PMID: 273218

DOI: 10.2307/67824


Related references

Introduction of short-range restrictions in a protein-folding algorithm involving a long-range geometrical restriction and short-, medium-, and long-range interactions. Proceedings of the National Academy of Sciences of the United States of America 78(11): 6584-6587, 1981

Effect of short- and long-range interactions on protein folding. Protein Journal 1(4): 281-304, 1982

Model of protein folding: inclusion of short-, medium-, and long-range interactions. Proceedings of the National Academy of Sciences of the United States of America 72(10): 3802-3806, 1975

On a generalized Levinthal's paradox: The role of long- and short range interactions in complex bio-molecular reactions, including protein and DNA folding. Progress in Biophysics and Molecular Biology 132: 57-79, 2018

Modeling the third loop of short-chain snake venom neurotoxins: roles of the short-range and long-range interactions. Proteins 42(1): 6, 2001

Modeling the third loop of short-chain snake venom neurotoxins: Roles of the short-range and long-range interactions. Proteins 42(1): 6-16, 2001

Short-range contact preferences and long-range indifference: is protein folding stoichiometry driven?. Journal of Biomolecular Structure and Dynamics 28(4): 603, 2011

Poly nucleotide folding in yeast phenylalanyl transfer rna elucidation of short range medium range and long range interactions of sugar phosphate sugar backbone and base using a blocked nucleotide probe. Biopolymers 21(10): 2033-2048, 1982

Importance of long-range interactions in protein folding. Biophysical Chemistry 77(1): 49-68, 1999

Influence of medium and long range interactions in protein folding. Preparative Biochemistry and Biotechnology 29(4): 339-351, 1999

Studies on protein folding, unfolding and fluctuations by computer simulation. III. Effect of short-range interactions. International Journal of Peptide and Protein Research 13(3): 235-252, 1979

Studies on protein folding unfolding and fluctuations by computer simulation part 3 effect of short range interactions. International Journal of Peptide & Protein Research 13(3): 235-252, 1979

Comparison between long-range interactions and contact order in determining the folding rate of two-state proteins: application of long-range order to folding rate prediction. Journal of Molecular Biology 310(1): 27-32, 2001

Logical analysis of the mechanism of protein folding III. Prediction of the strong long-range interactions. Journal of Molecular Biology 94(2): 257-281, 1975

Logical analysis of the mechanism of protein folding part 3 prediction of the strong long range interactions. Journal of Molecular Biology 94(2): 257-282, 1975