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Role of the agnoprotein in regulation of simian virus 40 replication and maturation pathways



Role of the agnoprotein in regulation of simian virus 40 replication and maturation pathways



Journal of Virology 61(3): 937-939



Analysis of two agnogene mutants, dl2304 deleted over the entire agnogene and in2379 carrying a 2-base insert, indicated that the mutant phenotype of small plaque formation must be the result of a defect late in the maturation pathway. Both mutants were removed from the pool of molecules available for replication with wild-type kinetics. Whereas dl2304 was somewhat reduced in its rate of progression from chromatin to previrions-virions, in2379, which produced even smaller plaques than dl2304 did, progressed with wild-type kinetics. Therefore, the agnoprotein was not required for progression from chromatin to previrions.

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Accession: 041289814

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PMID: 3027418


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