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Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio


Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio



Journal of Clinical Epidemiology 43(1): 55-59



ISSN/ISBN: 0895-4356

PMID: 2319281

DOI: 10.1016/0895-4356(90)90056-u

Samples sizes are calculated for case-control studies where 1:1 matching has been employed, and where the goal is the interval estimation of the odds ratio. The optimal sample size is defined to be the smallest value for which a 100(1 - alpha)% confidence interval for the log odds ratio will not exceed a specified width 2 delta with specified probability (1 - gamma). This approach is similar in spirit to the power-based approach for sample size determination when significance testing is the goal. Tables of sample sizes are presented for various choices of parameters. We also find considerable disagreement with a published method based on expected numbers of discordant pairs.

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Accession: 041303089

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